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Application of rhoifolin-hyperin composition in preparing medicine for treating and/or preventing neurodegenerative diseases

A neurodegenerative and hyperoside technology, which is applied in the direction of nervous system diseases, neuromuscular system diseases, drug combinations, etc., can solve the problem of undiscovered effects of drugs for neurodegenerative diseases of the cymbidium round leaf

Inactive Publication Date: 2018-02-02
JIANGXI SHANXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, it has not been found that the main components of Shanxiang round leaves have the effect of treating and / or preventing neurodegenerative diseases

Method used

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  • Application of rhoifolin-hyperin composition in preparing medicine for treating and/or preventing neurodegenerative diseases
  • Application of rhoifolin-hyperin composition in preparing medicine for treating and/or preventing neurodegenerative diseases
  • Application of rhoifolin-hyperin composition in preparing medicine for treating and/or preventing neurodegenerative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Preparation of Rhodorin and Hyperin Composition

[0025] Take 1,000g of the leaves of Cyperus japonica, add 12 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, add 10 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recover the ethanol, and pass the aqueous solution through the The treated D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 45% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% privetin The mixed total glycosides of Rhodorin, Hyperin, through silica gel column chromatography, Sephadex LH-20 column chromatography, respectively merge Rhodoside, Hyperoside fraction, crystallization, obtain Rhodoside (1.5 g, purity: 98.7%), hyperin (1g, purity: 98.2%) pure product.

Embodiment 2

[0027] Rhodorin (7g) and hyperin (3g) were mixed, stirred, ground, and mixed uniformly to obtain a rhodorin-hyperoside composition (10g).

Embodiment 3

[0029] Rhodorin (9g) and hyperin (1g) were mixed, stirred, ground, and mixed uniformly to obtain a rhodorin-hyperoside composition (10g).

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Abstract

The invention relates to application of rhoifolin-hyperin composition in preparing medicine for treating and / or preventing neurodegenerative diseases.

Description

technical field [0001] The present invention relates to the application of a Rhodorin and Hyperin composition in the preparation of medicines for treating and / or preventing neurodegenerative diseases. Background technique [0002] Neurodegenerative diseases are diseases caused by central nervous system dysfunction caused by progressive degeneration and necrosis of nerve cells, which are aggravated with the aging of the global population, including Alzheimer's disease (AD) and Parkinson's disease (Parkinson's disease, PD), amyotrophic lateral sclerosis (Atrophy lateral sclerosis, ALS), Huntington's disease (Huntington's disease, HD), stroke (Stroke) and cardiovascular dementia (Vascular dementia, VD). It mainly affects the cognitive function and motor function of patients, causing disability and high mortality rate, and brings great psychological and economic burden to patients' families and society. [0003] At present, most neurodegenerative diseases do not have a curative...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/28A61P25/16A61P25/14A61P25/00A61P21/00
CPCA61K31/7048A61K2300/00
Inventor 胡长玲阎阳本叶劲英谢宁张功俊谌丽芳谢纯平
Owner JIANGXI SHANXIANG PHARMA
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