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A screening method for chemical risk substances of nitroimidazole antibiotics in toiletries

A technology for nitroimidazoles and toiletries, which is applied in the field of screening chemical risk substances of nitroimidazole antibiotics, can solve the problems of unreported detection methods, insufficient preventive ability, lag in the supervision of chemical risk substances, etc. The effect of sustainable and healthy development, promotion of healthy and standardized development, and standardization of market economic rules and business order

Active Publication Date: 2020-02-07
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. The supervision of chemical risk substances in toiletries is relatively lagging behind, and the prevention ability is insufficient
However, there is no report on the detection method of toilet products using high-resolution mass spectrometry.

Method used

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  • A screening method for chemical risk substances of nitroimidazole antibiotics in toiletries
  • A screening method for chemical risk substances of nitroimidazole antibiotics in toiletries
  • A screening method for chemical risk substances of nitroimidazole antibiotics in toiletries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A method for detecting chemical risk substances of nitroimidazole antibiotics in toiletries, comprising the steps of:

[0049] After the pretreatment steps of extraction, centrifugation, purification, filtration and other pretreatment steps, the sample solution obtained by ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection; ultra-high pressure liquid chromatography-quadrupole In rod-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection, the chromatographic separation conditions are as follows:

[0050] Chromatographic column: CSH phenylhexyl column, length 50mm, inner diameter 2.1mm, particle size 1.7μm; column temperature: 40°C; flow rate: 0.45mLmin -1 ;Injection volume: 10μL, see Table 1 for mobile phase and gradient elution program:

[0051] Table 1 Chromatographic mobile phase and gradient elution program

[0052]

[0053] In the ultra-high pr...

Embodiment 2

[0061] 1. Instruments and reagents

[0062] Dionex UltiMate 3000 fast high-performance liquid chromatography system (Thermo Fisher, USA); QExactive Focus quadrupole-electrostatic field orbitrap high-resolution mass spectrometer (Thermo Fisher, USA); Milli-Q ultrapure water instrument (Millipore, USA); Vortex-Genie 2 vortex oscillator (Scientific Industries, USA).

[0063] Methanol, acetonitrile (chromatographically pure, American Thermo Fisher Company); ammonium hydroxide, formic acid (chromatographically pure, American DimaTechnology Company); laboratory water is deionized water. Carbon eighteen, N-propyl ethylenediamine and graphitized carbon black (Germany Macherey-Nagel company); Multi-wall carbon nanotubes (Germany Miltenyi Biotec GmbH company); Anhydrous magnesium sulfate, sodium chloride (Guangzhou Xilong Chemical Industry limited liability company); 0.22 μm microporous membrane (Pall Corporation, USA).

[0064] Prepare 500-1000μg mL respectively -1 The standard stoc...

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Abstract

The invention discloses a method for screening chemical risk substances such as nitroimidazole antibiotics in toiletries. The method comprises (1) establishing an accurate mass database and a mass spectral database of compounds to be detected, (2) pre-treating a toiletry sample through extraction, centrifugation, purification and filtration and carrying out ultrahigh-pressure liquid chromatography-quadrupole-electrostatic field orbitrap high resolution mass spectrometry analysis detection on the sample solution, and (3) comparing and analyzing the test result in the step (2) and the built accurate mass database and mass spectral database in the step (1) and carrying out nitroimidazole antibiotic chemical risk substance nitroimidazole antibiotic screening. The method has high accuracy, strong specificity and high sensitivity and can be applied to daily detection and quality control of the toiletries.

Description

technical field [0001] The invention relates to a screening method for chemical substances, in particular to a chemical risk of nitroimidazole antibiotics in cleaning products based on ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry Substance screening methods. Background technique [0002] 1. Chemical risk substances in toiletries have potential harmful effects on consumers' personal health. [0003] From the very beginning of its birth, toiletries have provided protection for people's pursuit of a clean, healthy and fashionable life. With the continuous development and progress of society, people's pursuit of a clean, healthy and fashionable lifestyle has also been continuously upgraded, thus driving the development of toiletries. The industry has stepped into the fast lane of development and upgrading. At present, there are a wide variety of products in the cleaning and care products market, and functio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 马强孟宪双白桦郭项雨胡明珠吕悦广闫萌萌陈萌
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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