Biological information processing method for analyzing circulating tumor DNA (deoxyribonucleic acid)

Abstract

The invention provides a biological information processing method for analyzing circulating tumor DNA (deoxyribonucleic acid). The method includes 1), performing cfDNA extraction, database creating and sequencing; 2), performing sequencing-data quality control and sequencing comparison; 3), performing sequencing data correction; 4), using two pieces of software to simultaneously perform gene mutation detection on the sequencing data corrected in the step 3) and summing and integrating analysis results of the software; 5), establishing a mutant trusted data set by the aid of a sequence corrected in the step 3) and using the data set to provide credibility support to a mutation result acquired in the step 4). The ctDNA in the cfDNA is taken as a detection object, detection can be performed by only collecting a small amount of peripheral blood of a subject, and conciseness and convenience in sample collection are achieved.

Description

technical field [0001] The invention belongs to the field of biotechnology, more specifically, it relates to a biological information processing method for circulating tumor DNA analysis. Background technique [0002] In recent years, due to environmental pollution and bad living habits, the morbidity and mortality of tumors have continued to increase, which has become the number one factor that endangers human health and survival. It is estimated that in the next 20 years, the number of new cancer cases in the world will reach 22 million each year, and the number of cancer deaths will also soar to 13 million during the same period. On average, 1 out of every 8 deaths will die from cancer. In China, 264 people per 100,000 people suffer from cancer every year, and 192 people per 100,000 people die of cancer every year. The 5-year survival rate of cancer patients in China is about 30%, far behind the 60% in developed countries, which shows that the situation of cancer prevent...

AI Technical Summary

Problems solved by technology

[0004] Due to the heterogeneity of tumors and individual differences among populations, tumor samples of the same tissue in different populations, different genders, and even different individuals in different living environments will have different genetic backgrounds. Therefore, it is particularly necessary to obtain individual genetic information

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