Bionic joint synovial fluid and its preparation method
A bionic joint and synovial fluid technology, applied in the field of bionic joint synovial fluid and its preparation, to achieve good compatibility, slow down the process, and relieve pain
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0026] BDDE was selected as the cross-linking agent, and the cross-linking degrees were 2%, 5%, 10%, and 20% respectively. ), the mass concentration of carboxymethyl chitosan in the cross-linked gel was 30mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 20 mg / mL and a pH value of 7.2. Among them, non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 5% cross-linked carboxymethyl chitosan, 10% cross-linked carboxymethyl chitosan, 20% cross-linked carboxymethyl chitosan The proportions of methyl chitosan are: 40%, 20%, 20%, 15%, 5%. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65 digital ULTRA-TURRAX® Package disperser from IKA Company was used to disperse for 30 min under the condition of 500 r / min , repeat the dispersion 5 times. After pulverization, the gel was taken out, kept at 121°C for 15 minutes for h...
Embodiment 2
[0028] Glutaraldehyde was used as the cross-linking agent, and the cross-linking degrees were 2%, 8%, and 15%, respectively. , the mass concentration of carboxymethyl chitosan in the cross-linked gel was 35 mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 25 mg / mL and a pH value of 7.2. Among them, the proportions of non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 8% cross-linked carboxymethyl chitosan, and 15% cross-linked carboxymethyl chitosan are respectively: 50 %, 30%, 18%, 2%. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65 digital ULTRA-TURRAX® Package disperser from IKA Company was used to disperse for 35 min under the condition of 800 r / min , repeat the dispersion 8 times. After the pulverization was completed, the gel was taken out, kept at 115°C for 30 minutes for high temperature and hi...
Embodiment 3
[0030] Epichlorohydrin was selected as the cross-linking agent, and the cross-linking degrees were 2%, 5%, 8%, 12%, 15% and other five cross-linked carboxymethyl chitosan gels (molecular weight 200 KDa, deacetylation degree 90%, substitution degree 1.2), the mass concentration of carboxymethyl chitosan in the cross-linked gel was 30 mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 20 mg / mL and a pH value of 7.2. Among them, non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 5% cross-linked carboxymethyl chitosan, 8% cross-linked carboxymethyl chitosan, 12% cross-linked carboxymethyl chitosan The proportions of methyl chitosan and 15% cross-linked carboxymethyl chitosan are: 40%, 20%, 15%, 10%, 10%, and 5%, respectively. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65digital ULTRA-TURRAX® Package disperse...
PUM
Property | Measurement | Unit |
---|---|---|
particle diameter | aaaaa | aaaaa |
molecular weight | aaaaa | aaaaa |
elastic modulus | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com