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Drug balloon and preparation method thereof

A balloon and drug technology, applied in the field of medical devices, can solve the problems of restricting the development of PCI and vascular restenosis, and achieve the effects of good adherence performance, prolonged continuous filling time, and better therapeutic effect.

Pending Publication Date: 2017-08-25
SHANGHAI XINZHI MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After treatment, 5-60% of the patients will have vascular restenosis in the short and medium term, which seriously limits the development of PCI.

Method used

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  • Drug balloon and preparation method thereof
  • Drug balloon and preparation method thereof
  • Drug balloon and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Figure 1-3 A specific embodiment of the drug balloon involved in the present invention is shown. In this embodiment, the drug balloon includes a balloon body 1 . The surface of the balloon body 1 is covered with the drug 2 for 360°. The balloon body 1 has three flaps 3 . The number of flaps 3 is not limited to three in the present invention. In the folded state, the medicine 2 on the inner surface of the flap 3 is folded inside, so it does not contact the blood vessel wall, thereby ensuring that this part of the medicine 2 will not be lost during the process of the balloon body 1 passing through the blood vessel. In the filled state, such as image 3 As shown, the medicine 2 on the inner surface of the flap 3 is exposed together with the rest of the medicine 2 (including the medicine 2 on the outer surface of the flap 3 ) to contact the blood vessel wall to exert the medicine effect. In this embodiment, the cross-section of the balloon body 1 is circular, so as t...

Embodiment 2

[0041] Figure 4 Another drug balloon of the present invention is shown. In the inflated state, the cross section of the balloon body 1 shows that a depression 4 is provided between adjacent flaps. The function of the depression 4 is to make the drug balloon not completely block the blood flow even in the inflated state, thereby prolonging the continuous filling time and providing more time for the drug release, thereby achieving a better effect. The rest of the designs are the same as in Example 1, all covering the drug 2 with 360° and having flaps 3. The number of recesses 4 is the same as the number of flaps 3 .

Embodiment 3

[0043] In the inflated state, the surface of the cross-section of the balloon body is provided with depressions, which facilitates the passage of blood flow. Unlike Embodiment 2, the recess is not limited to the recess between the flaps. The rest are the same as in Example 2.

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Abstract

The invention discloses a drug balloon. The drug balloon comprises a balloon body, wherein the balloon body is totally covered with a drug, that is, the surface of the balloon body is covered with the drug in 360 degrees; the balloon body has a folded state and a filling state; when the balloon body is in the folded state, a part of the drug is folded in the balloon body and is not contacted with the vascular wall; when the balloon body is in the filling state, the drug folded in the balloon body is exposed to be contacted with the vascular wall. The invention further discloses a preparation method of the drug balloon. According to the preparation method, the balloon body is covered with the drug through iopromide by adopting an extraction and / or ultrasonic spraying manner. According to the drug balloon, the complete circumference of a blood vessel can receive the drug by means of 360-degree drug coverage, so that the treatment effect is better, and the production is more convenient.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a drug balloon and a preparation method thereof. Background technique [0002] Cardiovascular stenosis is one of the main causes of coronary heart disease. Interventional therapy (Percutaneous Coronary Intervention, PCI) is an important means of treating cardiovascular stenosis. With the increase in the number of stents used, the problem of in-stent restenosis (ISR) has become increasingly serious. After treatment, 5-60% of patients will have vascular restenosis in the short and medium term, which seriously limits the development of PCI. [0003] In recent years, a new technology for preventing vascular restenosis after interventional therapy—drug balloons—has emerged. It is to coat the anti-intimal hyperplasia drug on the surface of the balloon. When the balloon reaches the diseased blood vessel wall and is stretched and filled, it contacts the intima of the blood vessel wall, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/10A61M25/00A61M25/098
CPCA61M25/0009A61M25/0108A61M25/1002A61M25/1029A61M31/00A61M2025/1031A61M2025/105A61M2025/1004A61M2025/0057A61M2025/0025
Inventor 盛卫文朱平
Owner SHANGHAI XINZHI MEDICAL TECH CO LTD
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