A kind of medicine for treating hair loss and preparation method thereof

A medicine and technology for making Polygonum multiflorum, which is applied in the field of medicine for treating hair loss and its preparation, can solve problems such as easy adhesion and agglomeration, slow conduction speed, low drying efficiency, etc., to reduce daily dosage, reduce dosage, and improve compliance Effect

Active Publication Date: 2020-02-11
GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the preparation process of the products recorded in the "Chinese Pharmacopoeia" is relatively traditional and simple, and some medicinal materials are directly used as powder without extraction. Not only are there many ineffective or even harmful ingredients such as impurities and heavy metals, but the extraction efficiency of active ingredients is not high, and 4 No. 0 capsules (specification: 0.5g per capsule) are required to be taken each time. The dosage is large, and many patients feel inconvenient to take it.
In addition, traditional wet granulation and steam box drying methods are used in the preparation process, and the prepared granules are easy to stick and agglomerate during the drying process, which requires continuous granulation, high labor intensity, and the heat conduction speed of the steam drying method It is very slow, the drying efficiency is low, and the material is heated unevenly, which will cause a temperature difference between the inside and outside of the heated material, which will affect the quality stability of the product. For example, the main active ingredient stilbene glycosides in Polygonum multiflorum will be destroyed by high temperature heating

Method used

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  • A kind of medicine for treating hair loss and preparation method thereof
  • A kind of medicine for treating hair loss and preparation method thereof
  • A kind of medicine for treating hair loss and preparation method thereof

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preparation example Construction

[0031] A preparation method of a medicine for treating hair loss, the medicine is Yangxue Shengfa Capsules, the preparation method mainly comprising: Angelica, Notopterygium, Chuanxiong using supercritical CO 2 Extraction, supercritical extract using β-cyclodextrin inclusion; make Polygonum multiflorum, Radix Paeoniae Alba, Gastrodia elata and supercritical CO 2 After the extracted medicinal residues are mixed, ultrasonic extraction is used, and the extract is concentrated in vacuum at low temperature to form the first thick paste; rehmannia glutinosa, papaya, and dodder are decocted in water, and the decoction is filtered and concentrated into the second thick paste; the above two After the thick paste is mixed evenly, it is dried under microwave vacuum at low temperature, and the obtained dry paste is pulverized, and after the prepared dry paste powder is mixed uniformly with the clathrate, an appropriate amount of auxiliary materials is added, granulated by dry method, and p...

Embodiment 1

[0051] A kind of medicine for treating alopecia, its preparation method is as follows: take by weighing 1050g of angelica, 410g of notopterygium, 410g of chuanxiong, adopt supercritical CO 2 Extraction, the extraction conditions are: extraction pressure 25Mpa, extraction temperature 50°C, analysis pressure 7Mpa, analysis temperature 40°C, extraction time 2 hours, to obtain 65g fat-soluble extract A and 1737g medicinal residue B; 205g, 1050g of Radix Paeoniae Alba, mixed with the remaining medicinal residue B of supercritical extraction, add 8 times the volume fraction of 65% ethanol solution for ultrasonic extraction twice, the first time for 2 hours, the second time for 1.5 hours, combine the alcohol extracts, filter After filtration, the filtrate was concentrated under reduced pressure (temperature 55° C.) to obtain 2455 g thick paste C, with a relative water density of 1.28 (50° C.); weigh 2050 g rehmannia glutinosa, 615 g papaya, and 1050 g dodder seed, add 10 times the amo...

Embodiment 2

[0053] A kind of medicine for treating alopecia, its preparation method is as follows: take by weighing 2100g of angelica, 820g of notopterygium, 820g of chuanxiong, adopt supercritical CO 2 Extraction, the extraction conditions are: extraction pressure 20Mpa, extraction temperature 60°C, analysis pressure 8Mpa, analysis temperature 50°C, extraction time 3 hours, to obtain 125g fat-soluble extract A and 3503g medicinal residue B; 410g, 2100g of Radix Paeoniae Alba, mixed with the residue B of supercritical extraction, add 7 times the volume fraction of 50% ethanol solution and ultrasonically extract 3 times, the first time is 1.5 hours, the second time is 1.5 hours, the third time is 1 hour , combined the alcohol extracts, filtered, and the filtrate was concentrated under reduced pressure (temperature 50°C) to obtain 4822g of thick paste C, with a relative density of 1.29 (50°C); weigh 4090g rehmannia glutinosa, 1230g papaya, and 2100g dodder seed, and add 12 times the amount ...

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Abstract

The invention discloses a drug for treating alopecia. The drug comprises the following raw materials, by weight part, 1050-3150 parts of Chinese angelica, 410-1230 parts of rhizoma et radix notopterygii, 410-1230 parts of rhizoma ligustici chuanxiong, 2050-6135 parts of prepared rehmannia roots, 1050-3150 parts of dodder seeds, 615-1845 parts of papayas, 2045-6135 parts of prepared fleeceflower roots, 205-615 parts of tall gastrodia tubers and 1050-3150 parts of debark peony roots. The invention further discloses a preparation method of the drug. The drug prepared through the method is high in extraction efficiency of effective components, has the effective components not prone to be damaged, is less in administration amount, and stable in quality.

Description

technical field [0001] The invention relates to the technical field of medicine preparation technology, in particular to a medicine for treating alopecia and a preparation method thereof. Background technique [0002] Hair loss is a common skin disease. Western medicine believes that it is mainly caused by androgen, excessive oil secretion and other reasons. Traditional medicine believes that "the kidney stores the essence, and its flower is in the hair. When the kidney qi is weak, the hair falls off, and the hair turns gray early", and "the hair is the rest of the blood." "The liver stores blood", and the same source of essence and blood transforms each other. Therefore, the quality of hair growth is directly related to the liver, kidney, and qi and blood. Most hair loss patients have deficiency of both liver and kidney, and qi and blood deficiency. Yangxue Shengfa Capsule is a pure traditional Chinese medicine preparation for treating hair loss. It follows the principle o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61P17/14
CPCA61K36/232A61K36/236A61K36/237A61K36/39A61K36/43A61K36/65A61K36/704A61K36/71A61K36/732A61K36/804A61K36/8988A61K2236/331A61K2236/37A61K2236/51A61K2300/00
Inventor 江涛彭红英杨滨宾陈晓坚刘敏珊曾利杰陈丽斯
Owner GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARM CO LTD
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