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Ephedrine extracting method

An extraction method and ephedrine technology, applied in the field of medicine, can solve the problems of heavy organic solvent pollution and high cost, and achieve the effect of stabilizing the extraction method

Inactive Publication Date: 2017-06-13
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, organic solvents such as xylene are heavily polluted and costly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Put the ephedra powder in a flask, add 5 times of distilled water (pH=2.0), heat and reflux for 1.5h, and filter; add 1% cellulase (based on the mass of ephedra) to the filter residue, hydrolyze at 45°C for 2h, and filter; Add distilled water 4 times (pH=7.5), heat to reflux for 1.5h, filter; combine the filtrates and dry them.

Embodiment 2

[0017] Put the ephedra powder in a flask, add 6 times of distilled water (pH=2.0), heat and reflux for 1.5h, and filter; add 1% α-amylase (based on the mass of ephedra) to the filter residue, hydrolyze at 50°C for 2h, and filter; Add distilled water 6 times (pH=7.5) to the filter residue, heat to reflux for 1.5h, filter; combine the filtrates, and dry to obtain.

Embodiment 3

[0019] Put the ephedra powder in a flask, add distilled water 7 times (pH=2.5), heat and reflux for 1.5h, and filter; add 1% cellulase and 1% α-amylase to the filter residue and mix 1:1 (based on the mass of ephedra ), hydrolyze at 45°C for 2 hours, and filter; add 4 times distilled water (pH=8.0) to the filter residue, heat and reflux for 1 hour, and filter; combine the filtrates and dry them.

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Abstract

The invention discloses a method for extracting ephedrine, which adopts a semi-bionic-biological enzyme extraction method, which overcomes the shortcomings of the semi-bionic method such as high extraction temperature under normal pressure and difficulty in separation and purification. The addition of enzymes is beneficial to the leaching and bio-enzyme extraction of active substances. Transformation can more effectively extract the ephedrine in ephedra without destroying the original ingredients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for extracting ephedrine. Background technique [0002] Ephedra, Latin name: Ephedra sinica Stapf, Ephedra family, Ephedra herb. For exogenous wind-cold, aversion to cold and fever, open lung qi, disperse wind-cold and relieve asthma. It is rich in alkaloids and is the main resource for extracting ephedrine. Ephedrine, ① can prevent bronchial asthma attacks and relieve mild asthma attacks, but it is not effective for acute severe asthma attacks. ②For hypotension and chronic hypotension caused by subarachnoid anesthesia or epidural anesthesia. ③Treat nasal congestion caused by nasal congestion and swelling caused by various reasons. [0003] According to patent documents, an extraction process of ephedrine (CN201210489938) adopts alkalization, xylene extraction, and oxalic acid extraction to extract high-purity ephedrine. Among them, organic solvents suc...

Claims

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Application Information

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IPC IPC(8): C07C213/10C07C215/30
CPCC07C213/10
Inventor 吴健民尹丹贺莲
Owner KAMP PHARMA
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