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Blood uric acid detection test paper

A technology for detecting test strips and blood uric acid, which is applied in color/spectral characteristic measurement, analysis through chemical reaction of materials, and material analysis through observation of the impact on chemical indicators, etc., which can solve the problem of long waiting time and the amount of blood drawn Many problems, to achieve the effect of simple preparation method, accurate measurement results and stable performance

Active Publication Date: 2017-04-26
中科嘉睿(天津)医疗科技发展有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many problems in this method, such as a large amount of blood drawn and a long waiting time

Method used

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Embodiment Construction

[0022] The present invention will be further described in detail below in conjunction with the embodiments, so that those skilled in the art can implement it with reference to the description.

[0023] This case lists the blood uric acid detection test paper of an embodiment, which is prepared by sequentially immersing the filter paper in liquid A, drying, immersing in liquid B, and then drying; wherein:

[0024] Solution A includes: PBS buffer, urate oxidase, peroxidase, 4-aminoantipyrine and surfactant;

[0025] Liquid B includes: 2-(3,5-dimethoxy-4-hydroxyphenyl)-4-ethoxyphenyl-5-[4-(dimethylamino)phenyl]-imidazole and alcohol solvent . 2-(3,5-Dimethoxy-4-hydroxyphenyl)-4-ethoxyphenyl-5-[4-(dimethylamino)phenyl]-imidazole is a chromogen.

[0026] Among them, the concentration of urate oxidase is preferably 30000-50000U / L.

[0027] Wherein, the concentration of peroxidase is preferably 30000-50000U / L.

[0028] Wherein, the concentration of 4-aminoantipyrine is preferably...

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Abstract

The invention discloses a blood uric acid detection test paper. The test paper is produced through immersing a filter paper in a liquid A, drying the immersed filter paper, immersing the dried filter paper in a liquid B, and drying the re-immersed filter paper, wherein the liquid A comprises a PBS buffer solution, urate oxidase, peroxidase, 4-aminoantipyrine and a surfactant; and the liquid B comprises 2-(3,5-dimethoxy-4-hydroxyphenyl)-4-ethoxyphenyl-5-[4-(dimethylamino)phenyl]-imidazole and an alcohol solvent. The blood uric acid detection test paper allows the urate oxidase to rapidly react with uric acid under an alkaline condition to generate hydrogen peroxide, and the hydrogen peroxide oxidizes a colorless dye into a colored dye under the action of peroxidase, so the test paper has an obvious color interval from colorlessness to dark blue color, is easy to visually distinguish, is machine-readable, and is not interfered by other substances in blood; and the test paper also has the advantages of simple production method, easiness in operation, stable performances and accurate detection result.

Description

technical field [0001] The invention relates to a detection test paper for in vitro diagnosis, in particular to a blood uric acid detection test paper. Background technique [0002] Uric acid is a product of purine metabolism. Under normal circumstances, 70% of uric acid comes from metabolism in the body, 30% comes from diet, and most of it is excreted by the kidneys through the circulatory system. Any problem in this pathway may lead to high uric acid. Studies have found that gout is clearly associated with elevated blood uric acid levels. In the hyperuricemia (HUA) crowd without gout symptoms, the annual incidence rate of gout in the group with blood uric acid greater than 9 mg / dl was 4.9%, the annual incidence rate in the group with 7-9 mg / dl was 0.5%, and that in the group with blood uric acid below 7 mg / dl It is only 0.1%, and the blood uric acid in gout patients is reduced to below 6mg / dl, and the gout attack and intra-articular crystal deposition can be reduced. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N21/31
CPCG01N21/31G01N21/78
Inventor 白鹏利
Owner 中科嘉睿(天津)医疗科技发展有限公司
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