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Compound moxidectin drops as well as preparation method and application thereof

A technology for compound moxidectin drops and moxidectin drops, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and non-active ingredients of oil/fat/wax, etc. Problems such as irritation and weakening of pesticide application effect, to achieve good insecticidal effect, improve the sense of use, and improve the effect of killing effect

Inactive Publication Date: 2017-03-22
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, although people have made considerable progress in the research on insecticides in vivo and in vitro, on the one hand, due to the generation of parasite resistance, the application effect of existing insecticides has been weakened year by year, and the insecticides have to be increased every year. Insecticide consumption, which not only caused the increase of cost, but also caused environmental pollution and a growing threat to human health; Whether it is for pets who are in daily contact with humans for a long time, or for the applicator, there are more serious sensory stimulation

Method used

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  • Compound moxidectin drops as well as preparation method and application thereof
  • Compound moxidectin drops as well as preparation method and application thereof

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preparation example Construction

[0057] The preparation method of the compound moxidectin drops of the present invention is relatively simple, and the drops of the present invention can be obtained by mixing the raw materials of each component, specifically:

[0058] The solvent used as a solvent in the present invention is divided into two parts, most of which are used in step 1) to dissolve imidacloprid by stirring, and the remaining small part is used in step 4) to dissolve BHA and / or BHT;

[0059] And in step 2), since there are two main raw material components of the drops of the present invention, there are also differences in the preparation method of this step. Specifically, if permethrin is not included in the raw material components, then this In the step, it is only necessary to add moxidectin to the solution obtained in step 1), and further stir and mix; if the raw material component contains permethrin, then add moxidectin and permethrin to the solution obtained in step 1) in, and further stir t...

Embodiment 1

[0071] According to the percentage by weight: 2.5% moxidectin, 10% imidacloprid, 2% propylene glycol, 2% moringa seed oil, 0.1% BHT, 1% eucalyptus oil, and the remaining α-pyrrolidone, weigh appropriate amount of each raw material ;

[0072] Then, prepare moxidectin drops as follows:

[0073] 1) Dissolving imidacloprid with most of α-pyrrolidone;

[0074] 2) Add moxidectin to the solution obtained in step 1), and continue to stir and mix;

[0075] 3) Add propylene glycol, Moringa seed oil and eucalyptus oil to the solution obtained in step 2), and continue to stir and mix for 20-30 minutes;

[0076] 4) After dissolving BHT with the remaining α-pyrrolidone, mix the obtained solution with the solution obtained in step 3), and filter the obtained mixed solution through filter paper or filter cloth to obtain the compound moxidectin drops of Example 1.

Embodiment 2

[0078] According to the percentage by weight: 1% moxidectin, 10% imidacloprid, 2% propylene glycol, 2% moringa seed oil, 0.1% BHT, 1% eucalyptus oil, and the remaining α-pyrrolidone, weigh appropriate amount of each raw material ;

[0079] Then, prepare the compound moxidectin drop of embodiment 2 according to the method described in embodiment 1.

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Abstract

The invention provides compound moxidectin drops as well as a preparation method and application thereof. The compound moxidectin drops have the advantages that moxidectin and ingredients with insecticidal effect, such as imidacloprid, are compounded and used, so that the drops have good insecticidal effect; meanwhile, in the drops, propylene glycol, moringa seed oil and eucalyptus oil are taken as transdermal agents, wherein the moringa seed oil and the eucalyptus oil are natural plant essential oil with fragrance and can cover up peculiar smell in the drops and improve sense of a user; and further the drops can be used for killing endoparasite and ectoparasite of animals due to good insecticidal effect. In the preparation method, the components of the drops are taken as raw materials and mixed to prepare corresponding drops, so that the preparation method provided by the invention has the advantages of simplicity, high efficiency, good insecticidal effect of the obtained drops, and the like.

Description

technical field [0001] The invention relates to the field of insecticides, in particular to compound moxidectin drops and its preparation method and application. Background technique [0002] With the development of my country's social economy and the acceleration of urbanization, the problems of independence, closeness, individualization and aging of urban residents' families have become increasingly prominent, and the ways of leisure, consumption and emotional sustenance of residents are also diversified. Flourishing in our cities. [0003] In recent years, my country's pet industry has developed rapidly. According to a conservative estimate, the number of pet dogs alone in China has exceeded 10 million, and the number of pets in Beijing, Shanghai and other cities has also reached the level of one million. [0004] With the vigorous development of the pet industry, the health status of pets is not optimistic. Fleas, ticks, mites, skin diseases, plague, Lyme disease and ot...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/44A61K31/365A61K31/4439A61P33/00A61P33/14A61K31/216
CPCA61K9/08A61K9/0014A61K31/216A61K31/365A61K31/4439A61K47/44A61K2300/00
Inventor 元晓琪寇贺红吴桂英蒲静君李汶潓
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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