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Method for extracting tanshinol

An extraction method and technology of danshensu, applied in the extraction of danshensu, the target component of danshensu, in the field of danshensu extraction, can solve the problems of low content and yield of danshensu, complicated process and complexity of danshensu, and achieve It is not easy to decompose and destroy, avoid the effect of more leaching of impurities, and low temperature

Inactive Publication Date: 2017-03-08
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of the above-mentioned existing high-temperature decoction reflux extraction and concentrated danshensu methods, the decoction time is long, the impurities are dissolved more, and the extracted salvianolic acid components are oxidized and decomposed with the decoction time, and

Method used

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  • Method for extracting tanshinol
  • Method for extracting tanshinol
  • Method for extracting tanshinol

Examples

Experimental program
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Embodiment 1

[0048] The present embodiment provides a kind of extraction method of Danshensu, described method comprises the following steps:

[0049] (1) Grind the salvia miltiorrhiza until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure acid water with a pH of 2.9 as the entrainer, the amount of the entrainer is 1:10 (W / V), and CO 2 As the extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 32MPa, and the temperature is 60°C; the separation pressure of the first separation tank is 13MPa, and the temperature is 50°C; the separation pressure of the second separation tank is 6MPa, and the temperature is 45°C The extraction agent flow rate is 18L / h; the extraction time is 90min; supercritical extraction is carried out to obtain the extract;

[0050] (2) After adjusting the pH of the extract obtained in step (1) to 9.5, put it into a sterilizer for transformation at 121°C for 60 minut...

Embodiment 2

[0058] The present embodiment provides a kind of extraction method of Danshensu, described method comprises the following steps:

[0059] (1) Grind the salvia miltiorrhiza until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure acid water with a pH of 3.10 as the entrainer, the amount of the entrainer is 1:5 (W / V), and CO 2 As the extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 26MPa, and the temperature is 55°C; the separation pressure of the first separation tank is 15MPa, and the temperature is 45°C; the separation pressure of the second separation tank is 7MPa, and the temperature is 40°C ; The extraction agent flow rate is 15L / h; The extraction time is 90min; Carry out supercritical extraction to obtain the extract;

[0060] (2) After adjusting the pH of the extract obtained in step (1) to 9.9, put it into a sterilizer for transformation at 121°C for 60 minutes,...

Embodiment 3

[0068] The present embodiment provides a kind of extraction method of Danshensu, described method comprises the following steps:

[0069] (1) Grind the salvia miltiorrhiza until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure acid water with a pH of 3.5 as the entrainer, the amount of the entrainer is 1:8 (W / V), and CO 2 As the extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 30MPa, and the temperature is 50°C; the separation pressure of the first separation tank is 10MPa, and the temperature is 45°C; the separation pressure of the second separation tank is 8MPa, and the temperature is 40°C ; The extraction agent flow rate is 12L / h; The extraction time is 90min; Carry out supercritical extraction to obtain the extract;

[0070] (2) After adjusting the pH of the extract obtained in step (1) to 8.7, put it into a sterilizer for transformation at 121° C. for 60 minutes...

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Abstract

The invention provides a method for extracting tanshinol. The method comprises the following steps: (1) feeding a pretreated salvia miltiorrhiza material to a supercritical CO2 extractor, and carrying out supercritical extraction in a manner of taking acid water with the pH of 2.0 to 4.0 as an entrainer, so as to obtain a liquid extract; and (2) adjusting the pH of the liquid extract obtained in the step (1) to 8 to 11, then, carrying out transformation at the temperature of 120 DEG C to 130 DEG C, and then, carrying out rotary-evaporation concentrating, thereby preparing the tanshinol. According to the method, the acid water serves as the entrainer, salvianolic acid ingredients are extracted from the salvia miltiorrhiza material to the maximum in one step through supercritical CO2 extraction, the obtained liquid extract is then subjected to high-temperature one-step transformation, and thus the tanshinol is obtained. According to the method, extraction and separation steps are reduced greatly, the operation is simple, the efficiency of extraction of the tanshinol is high, solvent residual is absent, natural active ingredients and thermo-sensitive ingredients are not prone to decomposed destruction, and thus the natural features of the extract can be maintained to the maximum.

Description

technical field [0001] The invention belongs to the technical field of extraction of traditional Chinese medicines, and relates to a method for extracting danshensu, in particular to a method for extracting danshensu, a target component of Danshen medicinal material. Background technique [0002] Danshensu, also known as Danshensu A, is a phenolic aromatic acid compound, brownish-yellow powder or yellow powder, and its sodium salt is white needle-like crystals. The structural formula is as follows: [0003] [0004] Pharmacological studies have shown that Danshensu has protective effects on the heart, such as the protective effect on myocardial ischemia-reperfusion injury and the delayed protective effect on cardiac microvascular endothelial cells; Protective effect on blood damage), preventive effect on atherosclerosis, effect on cell apoptosis, and anti-tumor effects, etc. It is mostly used for promoting blood circulation and removing blood stasis, regulating qi and rel...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C51/47C07C59/52
CPCC07C51/42C07C51/47C07C59/52Y02P20/54
Inventor 冯世明马贤鹏毕昌琼罗斌郁华军沈万燕
Owner GUIZHOU JINGFENG INJECTION
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