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Medicine composition for improving postoperative cognitive dysfunction of senile patient and preparation method thereof

A technology for cognitive impairment and composition, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, to achieve the effect of promoting nerve cell proliferation, without side effects, and with significant effects.

Inactive Publication Date: 2017-03-08
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports at home and abroad that the composition of Huajuhong, Polygonum multiflorum, Ginkgo biloba, Huanghuadoushuilian, Shiya tea and Shichangpu extracts can be used to improve cognitive dysfunction in elderly patients after coronary artery bypass surgery

Method used

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  • Medicine composition for improving postoperative cognitive dysfunction of senile patient and preparation method thereof
  • Medicine composition for improving postoperative cognitive dysfunction of senile patient and preparation method thereof
  • Medicine composition for improving postoperative cognitive dysfunction of senile patient and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] At room temperature, take 1 kg each of Huajuhong, Radix Polygoni Multiflori, Ginkgo biloba, Huanghua Daoshuilian, Shiya tea and Shichangpu (5kg in total), soak in 60kg of water for 30 minutes, heat to boiling and cook for 30 minutes, The residue is soaked in 40kg water for 30 minutes, heated to boiling and decocted for 30 minutes, then the two obtained solutions are combined, filtered through a 200-mesh filter, concentrated 20 times under reduced pressure, centrifuged, and the bottom residue is removed. The collected concentrated solution is Pharmaceutical composition of the present invention.

Embodiment 2

[0039] At room temperature, take 0.8kg of Huajuhong, 0.8kg of Radix Polygoni Multiflori, 1.2kg of Ginkgo biloba leaves, 1.2kg of Huanghuaduoshuilian, 1.2kg of Shiya tea and 1.2kg of Shichangpu (5.4kg in total), soak and extract with 64.8kg of water, Soak for 30 minutes, heat to boiling and decoct for 30 minutes, soak the residue in 43.2kg water for 30 minutes, heat to boiling and decoct for 30 minutes, then combine the two solutions, filter through a 200-mesh filter, and concentrate 20 times under reduced pressure , centrifuged to remove the residue at the bottom, and the concentrated liquid collected is the pharmaceutical composition of the present invention.

Embodiment 3

[0041] At room temperature, take 0.8kg of Huajuhong, 0.8kg of Radix Polygoni Multiflori, 1.5kg of Ginkgo biloba leaves, 1.5kg of Huanghuaduoshuilian, 1.5kg of Shiya tea and 1.5kg of Shichangpu (7.6kg in total), soak and extract with 91.2kg of water, Soak for 30 minutes, heat to boiling and decoct for 30 minutes, soak the residue in 60.8kg water for 30 minutes, heat to boiling and decoct for 30 minutes, then combine the two solutions, filter through a 200-mesh filter, and concentrate 20 times under reduced pressure , centrifuged to remove the residue at the bottom, and the concentrated liquid collected is the pharmaceutical composition of the present invention.

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Abstract

The invention discloses a medicine composition for improving postoperative cognitive dysfunction of a senile patient and a preparation method thereof. The medicine composition is prepared from exocarpium, prepared fleeceflower root, ginkgo leaves, Polygala fallax Hemsl, silvery aleuritopteris and acorus gramineus. The raw materials are mixed in proportion, water is added for soaking, two times of decoction is performed, filtration is performed, two times of filtrates are mixed, reduced-pressure concentration is performed, centrifugation is performed to obtain centrifugate, and concentration is performed to obtain the medicine composition. The medicine composition is prepared based on the characteristics and pathogenesis of coronary artery stenosis and according to treating effect observation on a large number of clinical cases, animal experiments prove that the composition has a good cognitive dysfunction improving effect, further clinical tests also show that the medicine composition has the remarkable effect of improving the life quality after the senile patient undergoes coronary artery bypass graft and is low in untoward effect and very safe.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for improving postoperative cognitive impairment of elderly patients and a preparation method thereof. Background technique [0002] The results of the national census show that in 2013 my country's elderly population has exceeded 200 million, and the aging level has increased from 13.26% in 2011 to 14.8%, which shows that my country has officially entered an aging society. Coronary heart disease is a common disease in the elderly. Coronary artery bypass surgery is widely used as an effective, definite, and routine treatment, which can improve the prognosis of patients with severe coronary artery disease. [0003] Cognition is a kind of human mental activity, which refers to the psychological process of individuals recognizing and understanding things. It consists of multiple cognitive domains, including memory, calculation, time and space...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P25/28
CPCA61K36/888A61K36/16A61K36/69A61K36/704A61K36/752A61K36/82A61K2236/331A61K2236/39A61K2300/00
Inventor 胡佳心朱伟黄羽
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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