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Diagnosis and/or typing marker for PCOS (polycystic ovarian syndrome) and application of preparation reagent

A technology for use and detection reagents, which is applied in the field of diagnosis and/or typing markers of polycystic ovary syndrome and preparation of reagents, can solve problems such as high cost and complicated diagnosis of polycystic ovary syndrome, and reduce the detection rate. Cost, Effects of Solving Diagnostic Complexity

Active Publication Date: 2017-02-22
王义明
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  • Abstract
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Problems solved by technology

[0007] One purpose of the present invention is to provide a set of markers for the current clinical problems of complex diagnosis and high cost of polycystic ovary syndrome, which can be combined to assist in the diagnosis and / or classification of polycystic ovary syndrome

Method used

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  • Diagnosis and/or typing marker for PCOS (polycystic ovarian syndrome) and application of preparation reagent
  • Diagnosis and/or typing marker for PCOS (polycystic ovarian syndrome) and application of preparation reagent
  • Diagnosis and/or typing marker for PCOS (polycystic ovarian syndrome) and application of preparation reagent

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Embodiment Construction

[0029] The present invention will be further described below in conjunction with specific examples, so that those skilled in the art can better understand the present invention and implement it, but the given examples are not intended to limit the present invention.

[0030] The following is only one of the exemplary embodiments of the present invention:

[0031] 1. Metabolomics study of plasma samples from PCOS patients

[0032] 1 material

[0033] 1.1 Case selection

[0034] All observed cases were 49 cases of blood plasma from patients in Peking Union Medical College Hospital, and 50 cases of plasma from healthy volunteers. The diagnostic criteria of PCOS refer to Rotterdam’s unified international standard in 2003, with two of the following three indicators: ① ovulatory disorder, abnormal menstruation (oligomenorrhea, amenorrhea) and infertility; ② kaoxiong, hirsutism and acne ; or hyperandremia, that is, the blood total testosterone level ≥ 2.2 nmol / L on the 3rd to 5th ...

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Abstract

The invention discloses a diagnosis and / or typing marker for the PCOS (polycystic ovarian syndrome) and an application of the preparation reagent and particularly relates to an application of cyclic guanosine monophosphate, dehydroepiandrosterone sulfate, palm sphingomyelin combined HDL-C (high-density lipoprotein cholesterol) and the left follicle number as the diagnosis and / or typing marker for the PCOS. Compared with existing PCOS diagnosis clinical indexes, the marker can realize the effect of distinguishing a PCOS subgroup I and a PCOS subgroup II through combined diagnosis of cyclic guanosine monophosphate, dehydroepiandrosterone sulfate and palm sphingomyelin. In combination of combined diagnosis of HDL-C (high-density lipoprotein cholesterol) and the left follicle number, the very high diagnosis accuracy is realized for a normal group, the PCOS subgroup I and the PCOS subgroup II, and accurate and effective index systems are provided for clinical disease diagnosis.

Description

technical field [0001] The invention belongs to the technical field of disease diagnosis based on biomarkers, and in particular relates to diagnostic and / or typing markers and reagents for polycystic ovary syndrome. Background technique [0002] Polycystic ovary syndrome (PCOS) was first proposed by Stein and Leventhal in 1935. It is an endocrine syndrome characterized by reproductive disorders and metabolic disorders. Persistent anovulation, hyperandrogenism, and insulin resistance are its important features. It is the most common endocrine disorder in women of childbearing age. Its biochemical changes, pathogenesis, and clinical manifestations are highly heterogeneous, and its etiology has not yet been elucidated. The treatment methods are still at the level of symptomatic treatment and ovulation induction, and there is no specific treatment method yet. [0003] Western medicine clinical diagnostic criteria for polycystic ovary syndrome (Rotterdam diagnostic criteria): ⑴ ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/726
Inventor 王义明罗国安
Owner 王义明
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