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Application of pimbidone in the preparation of medicaments for preventing and/or treating human herpesvirus infection

A technology of herpes virus and pingbetone, which is applied in the field of medicine, can solve problems such as no reports on the application of pingbetone, and achieve the effects of obvious antiviral activity, inhibition of cytopathic changes, and improvement of survival rate

Active Publication Date: 2019-07-12
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the application of pingbetone in the preparation of drugs for the prevention and / or treatment of human herpes virus diseases

Method used

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  • Application of pimbidone in the preparation of medicaments for preventing and/or treating human herpesvirus infection
  • Application of pimbidone in the preparation of medicaments for preventing and/or treating human herpesvirus infection
  • Application of pimbidone in the preparation of medicaments for preventing and/or treating human herpesvirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The protective effect of embodiment 1 pingbeketone on HSV-1 and HSV-2 infected cell pathology

[0039] 1. Experimental materials

[0040] Cells and viruses: African green monkey kidney cells (Vero cells), purchased from the ATCC cell bank in the United States, and preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute. Herpes virus type 1 (HSV-1) SM44 strain, herpes virus type 2 (HSV-2) Sav strain, provided by Wuhan Institute of Virology, Chinese Academy of Sciences, preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute, passaged in Vero cell culture, Store at -80°C.

[0041] Reagent: Acyclovir, purchased from Hubei Keyi Pharmaceutical Co., Ltd. DMEM medium, purchased from Nanjing Kaiji Biotechnology Development Co., Ltd., batch number: 20141024, cell growth medium containing 10% fetal bovine serum, 1 × 10 5 U / L penicillin, 100mg / L streptomycin. The cell maintenance solution is the same as the cell growth solution except for 2% f...

Embodiment 2

[0054] Example 2 Therapeutic effect of external administration of pingbeketone on guinea pig skin human herpesvirus type 1 infection

[0055] 1. Experimental materials

[0056] Reagent: Acyclovir cream, produced by Jiangsu Yabang Johnson Pharmaceutical Co., Ltd.

[0057] Animal: Dunkin-Harthey white-haired guinea pig, purchased from Wuhan Institute of Biological Products, Ministry of Health

[0058] Virus: Herpes virus type 1 (HSV-1) SM44 strain, provided by Wuhan Institute of Virology, Chinese Academy of Sciences, preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute, passaged in Vero cell culture, and preserved at -80°C.

[0059] 2. Experimental method

[0060] Dunkin-Harthey white-haired guinea pig, weighing 300-350g, male, fed vegetables and feed 3 times a day. The experiment shared 12 guinea pigs, 3 in each group, and divided them into 4 groups: acyclovir group, pingbetone high, medium and low dose groups. Each animal selected 6 dermatomes for model...

Embodiment 3

[0067] Therapeutic effect of embodiment 3 oral administration of pingbeiketone on guinea pig skin human herpesvirus type 1 infection

[0068] 1. Experimental materials

[0069] Reagent: Acyclovir, purchased from Hubei Keyi Pharmaceutical Co., Ltd.

[0070] Animal: Dunkin-Harthey white-haired guinea pig, purchased from Wuhan Institute of Biological Products, Ministry of Health

[0071] Virus: Herpes virus type 1 (HSV-1) SM44 strain, provided by Wuhan Institute of Virology, Chinese Academy of Sciences, preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute, passaged in Vero cell culture, and preserved at -80°C.

[0072] 2. Experimental method

[0073] Dunkin-Harthey white-haired guinea pig, weighing 300-350g, male, fed vegetables and feed 3 times a day. In the experiment, 12 guinea pigs were used, 3 in each group, and divided into 4 groups. The groups were divided into acyclovir group, pingbetone high-dose, medium-dose, and low-dose groups, and each guinea p...

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Abstract

The invention relates to the technical field of medicines, in particular to application of pingbeinone in preparation of drugs for preventing and / treating human herpes viral infection. It is found through research that the pingbeinone can inhibit reproduction of human herpes viruses, relieve the symptoms caused by the human herpes viruses, decreased death caused by the human herpes viral infection, improve the survival rate of rats and average survival rate and prolong the life and shows dose-dependent relation. It is shown that the pingbeinone can effectively prevent and treat the diseases caused by the human herpes viral infection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of pingbetone in the preparation of medicines for preventing and / or treating human herpes virus infection. Background technique [0002] Herpes simplex virus (HSV) belongs to the herpesvirus α subfamily, and its serotypes include human herpesvirus type 1 (HSV-1) and human herpesvirus type 2 (HSV-2). After HSV-1 infects the human body, it mainly causes cold sores, pharyngitis, keratitis, and even sporadic encephalitis and other serious diseases; HSV-2 mainly causes genital herpes through damaged skin and mucous membrane infection. HSV infection is a common infectious disease in humans, and both herpes simplex virus infection can cause long-term latent infection in the body. Clinically used antiherpes virus drugs are mainly nucleoside analogs, such as aciclovir, ganciclovir, etc. However, these drugs have a narrow antiviral spectrum, are prone to drug resistance,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/437A61P31/22
CPCA61K31/437
Inventor 萧伟苏真真王俨如陶晓倩曹亮王振中丁岗胡晗绯
Owner JIANGSU KANION PHARMA CO LTD
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