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A polymer nanoparticle capable of detecting hypochlorous acid and copper ions, preparation method and application

A technology for detecting hypochlorous acid and nanoparticles. It is applied in the fields of analytical chemistry, life science and environmental science. It can solve the problems of complex detection process, single detection method, and inability to realize detection. It achieves accurate detection results, low instrument interference, and Effect of Good FRET Correlation Ratio Detection Effect

Active Publication Date: 2018-05-15
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the shortcomings of the existing method for detecting hypochlorous acid or copper ions that the detection cost is high, the detection process is too complicated, the detection means is single, and the detection of multiple response modes of a probe cannot be realized, and a detection method can be provided. Polymeric nanoparticles of hypochlorous acid and copper ions that enable highly sensitive ratiometric detection of hypochlorous acid and copper ions

Method used

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  • A polymer nanoparticle capable of detecting hypochlorous acid and copper ions, preparation method and application
  • A polymer nanoparticle capable of detecting hypochlorous acid and copper ions, preparation method and application
  • A polymer nanoparticle capable of detecting hypochlorous acid and copper ions, preparation method and application

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Embodiment 1

[0034] A kind of polymer nanoparticle preparation that can detect hypochlorous acid and copper ion, comprises the following steps:

[0035] (1) Preparation of product 1.

[0036] Dissolve PEO-TTC (0.2 mmol), styrene (36 mmol), AEMH (4 mmol) and azobisisobutyronitrile (0.057 mmol) in 4 mL of 1,4-dioxane, ice bath condition Under vacuum and nitrogen cycle three times. The temperature was raised to 90°C for 4 h. After the reaction was completed, it was precipitated with an appropriate amount of diethyl ether (30 mL), centrifuged, and dried in vacuo to obtain the desired product 1.

[0037] (2) Using the product prepared in step (1) and rhodamine B isothiocyanate to synthesize product 2.

[0038] Dissolve the product 1 (0.03 mmol) synthesized in step (1) and rhodamine B isothiocyanate (0.054 mmol) in DMF (5 mL), and place the mixed solution in the dark under N 2 Stir at room temperature for 24 h under protected conditions. After the reaction, most (85-95%) of DMF was removed by...

Embodiment 2

[0042] A kind of polymer nanoparticle preparation that can detect hypochlorous acid and copper ion, comprises the following steps:

[0043] (1) Preparation of product 1.

[0044] Dissolve PEO-TTC (0.2 mmol), styrene (34 mmol), AEMH (6 mmol) and azobisisobutyronitrile (0.057 mmol) in 4 mL of 1,4-dioxane, ice bath condition Under vacuum and nitrogen cycle three times. The temperature was raised to 90°C for 4 h. After the reaction was completed, it was precipitated with an appropriate amount of diethyl ether (30 mL), centrifuged, and dried in vacuo to obtain the desired product 1.

[0045] (2) Using the product prepared in step (1) and rhodamine B isothiocyanate to synthesize product 2.

[0046] Dissolve the product 1 (0.03 mmol) synthesized in step (1) and rhodamine B isothiocyanate (0.054 mmol) in DMF (5 mL), and place the mixed solution in the dark under N 2 Stir at room temperature for 24 h under protected conditions. After the reaction, most (85-95%) of DMF was removed by...

Embodiment 3

[0050] A kind of polymer nanoparticle preparation that can detect hypochlorous acid and copper ion, comprises the following steps:

[0051] (1) Preparation of product 1.

[0052] Dissolve PEO-TTC (0.2 mmol), styrene (38 mmol), AEMH (2 mmol) and azobisisobutyronitrile (0.057 mmol) in 4 mL of 1,4-dioxane, ice bath condition Under vacuum and nitrogen cycle three times. The temperature was raised to 90°C for 4 h. After the reaction, it was precipitated with an appropriate amount of diethyl ether (20 mL), centrifuged, and dried in vacuum to obtain the desired product 1.

[0053] (2) Using the product prepared in step (1) and rhodamine B isothiocyanate to synthesize product 2.

[0054] Dissolve the product 1 (0.03 mmol) synthesized in step (1) and rhodamine B isothiocyanate (0.054 mmol) in DMF (5 mL), and place the mixed solution in the dark and N 2 Stir at room temperature for 24 h under protected conditions. After the reaction, most (85-95%) of DMF was removed by rotary evapora...

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Abstract

The invention discloses polymer nanoparticles capable of detecting hypochlorous acid and copper ions. The polymer nanoparticles are novel polymer nanoparticles prepared by taking a polyethylene glycol monomethyl ether chain transfer agent, styrene, 2-aminoethylmethacrylate hydrochloride, rhodamine B isothiocyanate and a 9,9-dioctyl polyfluorene-benzothiadiazole alternate copolymer as raw materials. The polymer nanoparticles can realize high-sensitivity ratio fluorescence detection on the hypochlorous acid and the copper ions in a pure water solution. Compared with an existing fluorescence detection technology, the prepared polymer nanoparticles have a double-ratio detection function and good biocompatibility; a synthetic route is simple and a detection method is simple and convenient; the polymer nanoparticles are applicable to amplified synthesis and actual production application, and have a great application prospect in the technical fields including analytical chemistry, life science, environmental science and the like.

Description

technical field [0001] The invention relates to technical fields such as analytical chemistry, life science and environmental science, and specifically relates to the preparation of polymer fluorescent nanoparticles with dual detection functions of hypochlorous acid and copper ions, and the detection of hypochlorous acid in water by the polymer fluorescent nanoparticles. And the application of copper ion detection. Background technique [0002] Hypochlorous acid (HOCl), as a very important reactive oxygen species in biological cells, acts as a killer in cellular immunity, and is also one of the important substances to maintain the redox balance in organisms. However, due to its high activity, low content, and uneven distribution in organisms, people have encountered some difficulties in in-depth research on its properties. Moreover, NaOCl is the main component of most disinfectants, and many domestic waters are currently treated with chlorine gas disinfection, which will in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L53/00C08L65/00C08F293/00C08F8/34G01N21/64
CPCC08F8/34C08F293/005C08L53/005C08L65/00G01N21/6428G01N2021/6432
Inventor 张培盛王宏陈建余茂林洪永想易平贵
Owner HUNAN UNIV OF SCI & TECH
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