Preparation and application of magnetic graphene drug-loading system

A magnetic graphene and graphene technology, applied in the field of nanomaterials, can solve the problems that have not yet been studied or reported on breast cancer with magnetic graphene, and achieve the effect of mild experimental conditions, simple operation, and good biocompatibility

Active Publication Date: 2016-12-07
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] At present, there is no research or report on the use of magnetic graphene loaded paclitaxel in the treatment of breast cancer

Method used

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  • Preparation and application of magnetic graphene drug-loading system
  • Preparation and application of magnetic graphene drug-loading system
  • Preparation and application of magnetic graphene drug-loading system

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Embodiment

[0044] Add 0.12g of GO to 100mL of 1% CTAB distilled aqueous solution, ultrasonically disperse in ice bath for 30min, stir for 6h, at 10000r min -1 Centrifuge and wash with distilled water several times. Mix the product with 200mL of 0.24g of PSS solution, ultrasonically disperse for 30min, stir for 6h, continue to wash with distilled water for 2 to 3 times, and dry in vacuum at 40°C. The obtained sample is the modified graphene oxide f- go.

[0045] Prepared 0.12g f-GO and 1g FeCl 3 ·6H 2 O was added to 50 mL of ethylene glycol, and ultrasonically stirred in an ice bath for 2 h to make Fe 3+ Attached to GO, then centrifuged to remove excess Fe 3+ . Ultrasonic dispersion in ethylene glycol for 30min to form a homogeneous suspension. Then 1 g of PEG and 3.6 g of NaAc were added to the above suspension, ultrasonicated for 30 min, and then stirred for 12 h to obtain a hydrothermal precursor, which was reacted at 200 °C for 12 h in a polytetrafluoroethylene-lined reactor. A...

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Abstract

The invention discloses a preparation method of a magnetic graphene drug-loading system. The preparation method comprises the following steps of: (1) modifying oxidized graphene by using two types of surface active agents, and synthesizing into magnetic oxidized graphene by a hydrothermal synthesis method; (2) modifying by an amphiphilic polymer PF127, reducing the magnetic oxidized graphene into magnetic graphene with good biocompatibility by hydrazine hydrate; (3) loading a hydrophobic anti-cancer drug (paclitaxel) onto the magnetic graphene by pi-pi stacking effect and preparing into the magnetic graphene drug-loading system with integration of an anti-cancer effect, imaging and biocompatibility; (4) culturing the magnetic graphene drug-loading system and MCF-7 breast cancer cells together, and detecting the cell toxicity by an MTT method. The invention discloses application of the magnetic graphene drug-loading system in treating the breast cancer. The magnetic graphene drug-loading system disclosed by the invention is good in drug dispersity, strong in magnetic responsibility, good in biocompatibility and high in drug loading amount, and can show better inhibiting effect for MCF-7 breast cancer cells under the condition of less use amount (200mug / mL).

Description

technical field [0001] The invention relates to the field of nanomaterials and biotechnology, in particular to a preparation method and application of a magnetic graphene drug-carrying system capable of tumor magnetic targeting and breast cancer treatment. Background technique [0002] Breast cancer is one of the most common malignant tumors in women. In my country, breast cancer accounts for 7% to 10% of all kinds of malignant tumors in the whole body, second only to cervical cancer. The incidence rate is about 18.7 per 100,000 people. The trend is obvious. Although great progress has been made in the early diagnosis and treatment of breast cancer in my country, 80% of breast cancer patients are still in the middle and advanced stages when they are discovered. Although most of the tumors can be removed by surgery, most of them cannot be cured, and the tumor will eventually recur And metastases, the treatment effect is poor. Therefore, paying attention to breast cancer and w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/337A61P35/00
CPCA61K31/337
Inventor 张小娟郝凌云蔡文斌潘青青王心怡张文静余林
Owner JINLING INST OF TECH
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