Lysine, vitamin and calcium composition comprising chiral isocompound and application of composition

A technology of calcium lysine and its composition, which is applied in the field of medicine and can solve problems such as waste, disadvantages, and increased treatment risks

Inactive Publication Date: 2016-11-23
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many shortcomings or deficiencies in the preparations of the prior art. For patients with traumatic brain injury or cerebrovascular patients or other diseases, some patients will have potential or obvious hyperchloremia or acidosis, which makes the preparations used for Such patients may have adverse reactions, etc., while patients with cerebrovascular diseases accompanied by hyperchloremia or acidosis have no obvious symptoms, and it is difficult to identify them from external signs, resulting in difficulties or problems with medication
The compound lysine granules in the prior art are also not suitable for patients with hyperchloremia, acidosis, and renal insufficiency in some cases, especially after taking or administering under circumstances that are unknown or difficult to know in advance Potential adverse consequences; moreover, the current unit dosage specification only has 900mg of lysine hydrochloride and 50mg of calcium gluconate, and does not contain higher dosage compositions or low weight compositions, which is not conducive to daily use Convenience; the longer you take it, the greater the waste
This causes problems in manufacturing, taking convenience, transportation and packaging, or it is not suitable for clinical application, and it is not conducive to saving human resources and building a resource-saving society. The unfavorable situation has been ignored or not improved for many years. It not only causes waste of social resources, but also increases treatment risks, etc.

Method used

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  • Lysine, vitamin and calcium composition comprising chiral isocompound and application of composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]The preparation of embodiment 1L-lysine vitamin calcium granules, prescription (1000 bags): L-lysine acetate 1016.24g, calcium gluconate monohydrate 50g, vitamin B 6 2g, vitamin B 1 3.5g; preparation process: take the prescription amount, each component after passing through a 60-mesh sieve, mix evenly according to the equal-increase method, measure the content of the main drug in the granules, and pack them in double-aluminum composite film packaging bags according to the dose , sealing, inspection, and finished product.

Embodiment 2

[0046] The preparation of embodiment 2 L-lysine vitamin calcium granules, prescription (1000 bags): L-lysine acetate 1016g, calcium gluconate monohydrate 50g, vitamin B 6 2g, vitamin B 1 3.5g, cyclamate 1g, xylitol 200g; preparation process: take the prescription amount, each component after passing through a 60-mesh sieve, mix evenly according to the method of equal increment, measure the content of each main drug in the granule, press The dose is divided into double-aluminum composite film packaging bags, sealed and inspected to obtain finished products.

Embodiment 3

[0047] The preparation of embodiment 3 L-lysine vitamin calcium granules, prescription (1000 bags): L-lysine acetate 1016.24g, calcium gluconate monohydrate 50g, vitamin B 6 2g, vitamin B 1 3.5g, sodium carboxymethyl cellulose 1.5g, soluble starch 30g, orange flavor 0.5ml; preparation process: take the prescription amount and each solid component after passing through an 80-mesh sieve, mix them evenly according to the method of equal increment, and mix them Dissolve the orange essence in an appropriate amount of 95% ethanol water (that is, the volume ratio of the two is: ethanol: water = 95:5, the following is similar), make soft materials, pass through a 40-mesh sieve to granulate, and dry at about 50 ° C for 2 Hours, after passing through a 24-mesh sieve for granulation, divide and pack in double-aluminum composite film packaging bags according to weight, and seal to obtain corresponding preparations.

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PUM

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Abstract

The invention provides application of lysine, calcium and vitamin composition comprising chiral isocompound and used for preventing or treating human and mammal L-lysine deficiency, calcium deficiency, retained growth, osteoporosis, craniocerebral trauma, syndrome insomnia of the craniocerebral trauma, memory improvement, nervous system inflammation, climacteric syndrome, osteoporosis, cerebrovascular disease concomitant hyperchloremia and the like in health-care food or drugs, so that the product can be applied to new intended population clinically or have better pertinence and better clinical safety and the like.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a lysine vitamin calcium pharmaceutical composition or compound lysine containing chiral isomer compounds for the prevention or treatment of lysine, calcium deficiency, craniocerebral trauma and its syndromes, etc. Pharmaceutical composition of acid and its preparation and use. Background technique [0002] Calcium ions are indispensable ions for various physiological activities of the body. It maintains the biological potential on both sides of the cell membrane, maintains normal nerve conduction function, etc., and the mechanism of action of some hormones is expressed through calcium ions. The main functions or mechanisms are as follows: 1. Calcium ion is a blood coagulation factor and participates in the blood coagulation process; 2. It participates in the contraction process of muscles (including skeletal muscles and smooth muscles) and promotes the beating...

Claims

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Application Information

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IPC IPC(8): A61K31/51A61K31/198A61P3/02A61P3/14A61P25/00A61P19/10A61P25/20A61P25/28A61P15/12A61P39/02A23L1/29A61K31/191A61K31/4415
Inventor 刘力
Owner 刘力
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