Anti-depression drug taking dendritic cell-associated C type plant lectin-1 as target and screening method of anti-depression drug

Abstract

The invention provides an anti-depression drug, which is characterized in that a medicinal ingredient of the anti-depression drug takes dendritic cell-associated C type plant lectin-1 as a target; and through bonding, activation and / or up-regulated expression of the dendritic cell-associated C type plant lectin-1, an anti-depression effect is achieved. The dendritic cell-associated C type plant lectin-1, as a novel therapeutic drug design target, is expected to promote screening of anti-depression drugs which are based on an ingredient activating a Dectin-1 receptor.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an antidepressant drug targeting dendritic cell-related C-type lectin-1 and a screening method thereof. Background technique [0002] Depression has become a common and frequently-occurring disease in modern society, and its incidence is still increasing. Symptoms are characterized by depressed mood, loss of interest, slow thinking, and decreased speech and actions. Severe depression has world-weary or suicidal thoughts. The suffering caused by such diseases to patients and their families, as well as the loss to society, are unmatched by many other diseases. According to the report published by the World Health Organization (WHO), affective disorder has become the fourth largest disease in the world, and the number of depressed patients in the world has reached 340 million. The current incidence of depression in China is about 4%. At least 26 million people in Chi...

AI Technical Summary

Problems solved by technology

[0008] However, up to now, Dectin-1 has not been reported as the target of antidepressant drugs and its application in screening drugs with potential antidepressant efficacy

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