Labeled molecular agents for imaging cystine/glutamate anti porter

An imaging agent, CH2 technology, applied in preparations for in vivo experiments, analytical materials, in vivo radioactive preparations, etc., can solve the problems of difficult verification of biomarkers

Inactive Publication Date: 2016-08-31
GENERAL ELECTRIC CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

While such specific molecular contrast agents may be of great utility for disease imaging and diagnosis, the validation of truly specific biomarkers has proven difficult
Even if an agent is established for this specific biomarker, the market for this agent will be limited by the prevalence of this indication

Method used

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  • Labeled molecular agents for imaging cystine/glutamate anti porter
  • Labeled molecular agents for imaging cystine/glutamate anti porter
  • Labeled molecular agents for imaging cystine/glutamate anti porter

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Embodiment Construction

[0020] In order to more clearly and concisely describe and point to the claimed subject matter, the following definitions for specific terms used in the following description and appended claims are provided.

[0021] In the context of the present invention, alkyl is intended to include linear, branched or cyclic hydrocarbon structures and combinations thereof, including lower alkyl and higher alkyl. Preferred alkyl is C 20 or less than the alkyl group. Lower alkyl means an alkyl group of 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, including methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl and tert-butyl. Higher alkyl means an alkyl group having 7 or more carbon atoms, preferably 7 to 20 carbon atoms, including n-heptyl, sec-heptyl and tert-heptyl, octyl and dodecyl. Cycloalkyl is a subset of alkyl, including cyclic hydrocarbon groups of 3 to 8 carbon atoms. Examples of cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl and norbornyl. Alkenyl and ...

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Abstract

Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine / glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine / glutamate antiporter and subsequent detection.

Description

[0001] Statement Regarding Federally Funded Research and Development [0002] This invention was made with Government support under Contract 5R01EB014250-02 awarded by the National Institutes of Health (NIH). The government has certain rights in this invention. Background of the invention [0003] The present invention relates generally to labeled molecular imaging agents, and more particularly to imaging agents that are taken up by cells via the cystine / glutamate transporter. [0004] The concept of molecular imaging enables specific contrast enhancement of molecular markers of pathology and requires targetable biomarkers that are specifically regulated in certain pathological indications. While such specific molecular contrast agents may be of great utility for disease imaging and diagnosis, the validation of truly specific biomarkers has proven difficult. Even if an agent were established for this specific biomarker, the market for this agent would be limited by the preva...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/04
CPCA61K51/0406C07B59/002A61K49/0004A61K51/0446G01N33/5091
Inventor B.A.海J.M.韦布斯特
Owner GENERAL ELECTRIC CO
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