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Medicinal composition for treating liver and kidney Yang deficiency type narcolepsy

A technology for narcolepsy and composition, which is applied in the field of traditional Chinese medicine, can solve the problems of sodium oxybate, such as multiple indications, gastrointestinal dysfunction, and obvious adverse reactions, and achieve abundant drug sources, convenient administration, and no toxic and side effects Effect

Inactive Publication Date: 2016-08-03
邱发龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional central nervous system stimulants are rarely used because of obvious adverse reactions
New central stimulants such as modafinil have good safety, but there are adverse reactions such as headache, nausea, anxiety, tension, dry mouth, and diarrhea; sodium oxybate has many indications and a wide range of applications, but it also has dizziness, Ataxia, weight loss, depression, gastrointestinal dysfunction and other adverse reactions
Antidepressants are commonly used clinical anti-cataplexy drugs, which have certain effects on sleep paralysis and hypnagogic hallucinations, but have more adverse reactions than other drugs

Method used

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  • Medicinal composition for treating liver and kidney Yang deficiency type narcolepsy
  • Medicinal composition for treating liver and kidney Yang deficiency type narcolepsy

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Embodiment 1 capsule

[0036] Prescription: 12 parts of Geshanxiao, 15 parts of Cuscuta, 8 parts of Evodia, 6 parts of Mulberry, 5 parts of Asarum, 8 parts of Agarwood, 12 parts of Poria, 10 parts of Shichangpu, 10 parts of Albizia bark.

[0037] Preparation method: Take asarum, agarwood, calamus, and Albizia juniper, grind them into particles with an average particle size of 40-50 μm, add 8 times the amount of 50% ethanol aqueous solution, and use ultrasonic extraction. After ultrasonic extraction is completed, take the filtrate and depressurize Concentrate into a thick paste to obtain extract A, and set aside, wherein the extraction conditions include: ultrasonic power of 130-160W, extraction temperature of 30-50°C, and extraction time of 20-30min;

[0038] Add water to decoct Geshanxiao, Cuscuta, Evodia, Sangjisheng, and Poria cocos twice. The first decoction is 1.5-2.0 hours, and the amount of water added is 8 times the total weight of the decocted medicinal materia...

Embodiment 2

[0039] Embodiment 2 capsules

[0040] Prescription: 15 parts of Geshanxiao, 15 parts of Cuscuta, 10 parts of Evodia rutaecarpa, 5 parts of Sangjisheng, 5 parts of Asarum, 12 parts of Agarwood, 15 parts of Poria cocos, 12 parts of Shichangpu, 15 parts of Albizia bark.

[0041] Preparation method: Grind asarum, agarwood, calamus, and Albizia julibrissin into particles with an average particle size of 30-40 μm, add 7 times the amount of 50% ethanol aqueous solution, and use ultrasonic extraction. After ultrasonic extraction is completed, take the filtrate and depressurize Concentrate into a thick paste to obtain extract A, and set aside, wherein the extraction conditions include: ultrasonic power of 130-160W, extraction temperature of 30-50°C, and extraction time of 20-30min;

[0042] Add water to decoct Geshanxiao, Cuscuta, Evodia, Sangjisheng, and Poria cocos twice. The first decoction is 1.5-2.0 hours. The amount of water added is 7 times the total weight of the decocted medic...

Embodiment 3

[0043] Embodiment 3 capsules

[0044] Prescription: 12 parts of Geshanxiao, 13 parts of Cuscuta, 10 parts of Evodia rutaecarpa, 8 parts of Sangjisheng, 5 parts of Asarum, 7 parts of Agarwood, 10 parts of Poria, 8 parts of Shichangpu, and 12 parts of Albizia bark.

[0045] Preparation method: Take asarum, agarwood, calamus, and Albizia juniper, and grind them into particles with an average particle size of 10-30 μm, add 8 times the amount of 50% ethanol aqueous solution, and use ultrasonic extraction. After ultrasonic extraction is completed, take the filtrate and depressurize Concentrate into a thick paste to obtain extract A, and set aside, wherein the extraction conditions include: ultrasonic power of 130-160W, extraction temperature of 30-50°C, and extraction time of 20-30min;

[0046] Add water to decoct Geshanxiao, Cuscuta, Evodia, Sangjisheng, and Poria cocos twice. The first decoction is 1.5-2.0 hours, and the amount of water added is 10 times the total weight of the de...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a medicinal composition for treating liver and kidney Yang deficiency type narcolepsy and a preparation method thereof. The medicinal composition is prepared by taking cynanchum wilfordii, cuscuta chinensis, fructus evodiae, parasitic loranthus, asarum, agilawood, tuckahoe, rhizoma acori graminei and cortex albiziae as medicinal raw materials and formulating elaborately. The whole formula has the effects of warming the kidney and the liver, restoring consciousness and inducing resuscitation, and has an excellent effect on the liver and kidney Yang deficiency type narcolepsy formed by liver Yang deficiency because the liver Yang is damaged by the fact that liver vessels cannot be warmed or cold-pathogen attacks directly due to kidney Yang deficiency.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating narcolepsy of liver and kidney yang deficiency type and a preparation method thereof. Background technique [0002] Narcolepsy is a chronic central nervous system dysfunction disease, the main clinical features are irresistible excessive daytime sleepiness, nighttime sleep disturbance and pathological rapid eye movement sleep (REM) symptoms (triggered by intense emotion) episodic shattering, sleep paralysis, and hypnic hallucinations). The etiology of narcolepsy is unknown, and the prevalence rate is about 0.03%-0.16%. There are slight differences in reports from different countries, and there is no significant difference in the incidence rate between men and women. Narcolepsy often accompanies the whole life, seriously affects the quality of life of patients, and may even lead to accidents and endanger life. For example, child...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P25/00
CPCA61K36/076A61K36/185A61K36/268A61K36/27A61K36/39A61K36/48A61K36/754A61K36/835A61K36/888A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 邱发龙
Owner 邱发龙
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