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Composite hydrocolloid and preparation method thereof and hydrocolloid dressing and preparation method of hydrocolloid dressing

A technology of hydrocolloid and hydrocolloid layer, which is applied in capsule delivery, microcapsules, pharmaceutical formulations, etc. It can solve the problems of unproven safety, lack of adsorption, and unsustainable efficacy, so as to improve the healing effect and benefit growth , the effect of promoting wound healing

Inactive Publication Date: 2016-07-27
KANGDIFEI SUZHOU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, epidermal growth factor (EGF) is mostly added in gel or emulsion materials, which is a skin care type and does not have adsorption properties. It must be used with other auxiliary materials. Durable, safety to be demonstrated

Method used

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  • Composite hydrocolloid and preparation method thereof and hydrocolloid dressing and preparation method of hydrocolloid dressing
  • Composite hydrocolloid and preparation method thereof and hydrocolloid dressing and preparation method of hydrocolloid dressing
  • Composite hydrocolloid and preparation method thereof and hydrocolloid dressing and preparation method of hydrocolloid dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A hydrocolloid dressing, its preparation method is as follows:

[0032] Step (1), heating 40 parts by weight of polyisobutylene medical hot-melt adhesive to 110°C in a mixer to melt to form component A;

[0033] Step (2), mixing 10 parts by weight of the epidermal growth factor stock solution and 10 parts by weight of hyaluronic acid microcapsules at 2°C to prepare component B;

[0034] Step (3), adding 20 parts by weight of sodium carboxymethyl cellulose and 0.5 parts by weight of pectin to component A, stirring at a constant temperature in vacuum at 110°C for 50 minutes, then adding component B, vacuuming at 100°C Stir at constant temperature for 5 minutes to make a composite hydrocolloid;

[0035] Step (4), injection molding the composite hydrocolloid on the polyurethane film, and then performing aging treatment at 35° C. for 60 hours to form the composite hydrocolloid layer, covering the composite hydrocolloid layer with the polyurethane film, and then molding it t...

Embodiment 2

[0037] A hydrocolloid dressing, its preparation method is as follows:

[0038] Step (1), heating 100 parts by weight of polyisobutylene medical hot-melt adhesive to 150°C in a mixer to melt to form component A;

[0039] Step (2), mixing 30 parts by weight of the epidermal growth factor stock solution and 30 parts by weight of hyaluronic acid microcapsules at 8°C to prepare component B;

[0040] Step (3), adding 40 parts by weight of sodium carboxymethyl cellulose and 5 parts by weight of pectin to component A, stirring at a constant temperature in vacuum at 130°C for 100 min, then adding component B, vacuuming at 120°C Stir at constant temperature for 15 minutes to make a composite hydrocolloid;

[0041] Step (4), injection molding the composite hydrocolloid on the polyurethane film, and then performing aging treatment at 65° C. for 60 h to form the composite hydrocolloid layer, covering the composite hydrocolloid layer with release paper, and then molding into a suitable Th...

Embodiment 3

[0043] A hydrocolloid dressing, its preparation method is as follows:

[0044] Step (1), heating 70 parts by weight of polyisobutylene medical hot-melt adhesive to 130°C in a mixer to melt to form component A;

[0045] Step (2), mixing 20 parts by weight of the epidermal growth factor stock solution and 20 parts by weight of hyaluronic acid microcapsules at 5°C to prepare component B;

[0046] Step (3), add 30 parts by weight of sodium carboxymethyl cellulose and 2 parts by weight of pectin to component A, stir at 120°C for 70 minutes at a constant temperature in vacuum, then add component B, and vacuum at 110°C Stir at constant temperature for 10 minutes to make a composite hydrocolloid;

[0047]Step (4), injection molding the composite hydrocolloid on the non-woven fabric, then performing aging treatment at 45° C. for 60 h to form the composite hydrocolloid layer, covering the composite hydrocolloid layer with release paper, and then molding into It is suitable for the sha...

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PUM

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Abstract

The invention relates to composite hydrocolloid and a preparation method thereof and a hydrocolloid dressing. The composite hydrocolloid is prepared from, by weight, 10-30 parts of epidermal growth factors, 10-30 parts of microcapsules, 20-40 parts of sodium carboxymethylcellulose, 0.5-5 parts of pectin and 40-100 parts of an adhesive. The EGF hydrocolloid dressing is wide in application range, can be suitable for nursing of various skin wound surfaces, has the functions of regenerating, repairing, inflammation diminishing, bacterium resisting and wound discharge adsorbing, constructs a wet environment beneficial for wound recovery, greatly increases the regeneration speed of wound tissue, improves the self repairing capacity of wounds, is beneficial for growth of regenerated tissue and can promote wound healing and effectively prevent scar forming.

Description

technical field [0001] The invention relates to a composite hydrocolloid, a hydrocolloid dressing and a preparation method thereof. Background technique [0002] Hydrocolloid functional dressing is a new type of dressing with the advantages of adsorption, waterproof, anti-adhesion, and moisturizing. At present, hydrocolloid functional dressings are widely used in a wide range of applications. The materials used and the auxiliary materials added determine different functional characteristics and types of wounds to be treated. The quality of hydrocolloid dressings on the market varies greatly. For different wound characteristics, hydrocolloid functional dressings with good safety and specific functions are required. [0003] A number of hydrocolloid or epidermal growth factor (EGF) patents have been retrieved from domestic and foreign patents. This type of hydrocolloid application mostly uses chitosan, calcium alginate fiber, silver ions and other auxiliary materials, all of ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0014A61L26/0023A61L26/008A61L2300/404A61L2300/414A61L2300/622
Inventor 周晓宁吴建中刘菊园周永乐
Owner KANGDIFEI SUZHOU BIOTECH CO LTD
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