Pharmaceutical composition containing nitrendipine and capable of treating hypertension and preparation method thereof

A technology for nitrendipine and a composition is applied in the field of pharmaceutical compositions for the treatment of hypertension and the field of preparation thereof, which can solve problems such as restricting the use of nitrendipine, and achieve the effects of less side effects, improved therapeutic effect, and avoidance of allergic reactions

Inactive Publication Date: 2016-07-20
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of nitrendipine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0039] Nitrendipine 10g, flat bud 3000g, straw mushroom 3000g, cicada slough 3000g, dripping beads 3000g.

[0040] The preparation method of the pharmaceutical composition for treating hypertension:

[0041] a. Add water to decoct flat buds, straw mushrooms, cicada sloughs, and dripping drops twice, add 7 volumes of water for the first time, decoct for 1.5 hours, add water for 5 times the volume of the medicine for the second time, decoct for 1 hour, Combine the decoction and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing the nitrendipine with the dry po...

Embodiment 2

[0047] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0048] Nitrendipine 7.5g, flat bud 3500g, straw mushroom 2500g, cicada slough 3500g, dripping beads 2500g.

[0049] The preparation method of the pharmaceutical composition for treating hypertension:

[0050] a. Add water to decoct flat buds, straw mushrooms, cicada sloughs, and dripping drops for 2 times. For the first time, add 8 times the volume of the medicine and decoct for 2 hours. For the second time, add water 6 times the volume of the medicine, and decoct for 1.5 hours. Combine the decoction and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mixing t...

Embodiment 3

[0056] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0057] Nitrendipine 12.5g, flat bud 2500g, straw mushroom 3500g, cicada slough 2500g, dripping beads 3500g.

[0058] The preparation method of the pharmaceutical composition for treating hypertension:

[0059] a. Add water to decoct flat buds, straw mushrooms, cicada sloughs, and dripping drops for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add 4 times the volume of medicine for the second time, decoct for 0.5 hours, Combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing the nitrendipine with the dry powder...

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PUM

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a pharmaceutical composition containing nitrendipine and capable of treating hypertension and a preparation method thereof. The pharmaceutical composition containing nitrendipine and capable of treating hypertension is prepared from the following active pharmaceutical ingredients in parts by weight: 5-15 parts of nitrendipine, 2000-4000 parts of gentianopsis barbata, 2000-4000 parts of straw mushroom, 2000-4000 parts of periostracum cicada and 2000-4000 parts of tuber of cordate pinellia. According to the pharmaceutical composition, traditional Chinese medicines are combined with the nitrendipine, so that common adverse reactions of the nitrendipine can be avoided, and the treatment effect on hypertension is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing nitrendipine for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world....

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P9/12A61K31/4422A61K35/64
CPCA61K31/4422A61K35/63A61K36/07A61K36/515A61K36/8888A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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