Rakicidins compounds Rakicidin B1 and preparation method thereof

A compound and drug technology, applied in biochemical equipment and methods, microorganism-based methods, microorganisms, etc., can solve the problem of high recurrence rate

Active Publication Date: 2016-07-13
FUJIAN INST OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Anaerobic Clostridium difficile infection is the primary cause of antibiotic-associated diarrhea in hospitals. Metronidazole, vancomycin, and fetamycin are currently...

Method used

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  • Rakicidins compounds Rakicidin B1 and preparation method thereof
  • Rakicidins compounds Rakicidin B1 and preparation method thereof
  • Rakicidins compounds Rakicidin B1 and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of RakicidinB1

[0037] Step 1: The fermentation and culture conditions of Micromonospora strain FIM02-523 refer to the literature (Jiang Hong, Lin Ru, Zheng Wei, etc. The separation, identification and biological biological activity [J]. Chinese Journal of Antibiotics, 2006, 31(5): 267-270).

[0038] Step 2: Centrifuge the FIM02-523 fermentation broth obtained in Step 1 at 4500rpm for 15 minutes to obtain the mycelium residue, soak the obtained mycelium residue with 2 times the volume of anhydrous methanol or ethanol overnight, and sterilize the bacteria containing alcohol The silk residue was centrifuged again at 4500 rpm for 15 minutes, and the supernatants were combined to obtain a fermentation extract.

[0039] Step 3: HP20 macroporous resin adsorption column chromatography (diameter-to-height ratio 1:5-1:10, column volume 1.5-2.5L): use fermentation extract (40-60L) with 50%-55% Alcohol concentration, the flow rate is 40ml / min for upper column adsorp...

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Abstract

The invention relates to the field of medicine, in particular to Rakicidins compounds Rakicidin B1. Pharmacodynamic tests prove that the Rakicidin B1 can be applied to treatment of diseases such as diarrhea, digestive tract inflammation, oral inflammation, skin acne and the like caused by solid tumors such as stomach cancer, liver cancer, breast cancer, pancreatic cancer, intestinal cancer in a tumor hypoxia condition as well as anaerobic bacteria.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a Rakicidins compound RakicidinB1. Pharmacodynamic tests have proved that RakicidinB1 of the present invention has the ability to treat solid tumors such as gastric cancer, liver cancer, breast cancer, pancreatic cancer, intestinal cancer and anaerobic tumors. Diarrhea caused by bacteria, digestive tract inflammation, oral inflammation and skin acne and other diseases. Background technique [0002] The anti-cancer drug market has grown rapidly in recent years. In 2014, the global sales of anti-cancer drug market reached 100 billion US dollars; by 2018, the anti-cancer drug market will reach 147 billion US dollars, with a compound growth rate of 11.6%. The research and development of anti-cancer drugs will make huge profits . Hypoxia is one of the characteristics of malignant solid tumors. Hypoxia is closely related to tumor angiogenesis, invasion and metastasis, resistance to rad...

Claims

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Application Information

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IPC IPC(8): C07K5/062C12P21/02C12N1/20A61K38/05A61P35/00A61P31/04A61P1/12A61P29/00A61P1/00A61P1/02A61P17/10C12R1/29
CPCA61K38/00C07K5/06017C12P21/02C12N1/205C12R2001/29
Inventor 林风江红连云阳王传喜江宏磊赵薇陈丽周剑方东升陈晓明
Owner FUJIAN INST OF MICROBIOLOGY
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