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Glioma typing system based on IDH1-R132H and ATRX expression

A technology for IDH1-R132H and glioma, which is applied in analytical materials, biomaterial analysis, measuring devices, etc., can solve the problem of inability to accurately judge the prognosis of patients, inability to fully reflect the biological behavior of tumors, and the difficulty of clearly and objectively diagnosing glioma Pathological type and other issues

Inactive Publication Date: 2016-06-15
江涛 +2
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  • Application Information

AI Technical Summary

Problems solved by technology

At present, the diagnosis of glioma is only based on morphology. It is difficult to clearly and objectively diagnose the pathological type of glioma, nor can it fully reflect the biological behavior of the tumor. It cannot accurately judge the prognosis of patients and guide postoperative clinical treatment.

Method used

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  • Glioma typing system based on IDH1-R132H and ATRX expression
  • Glioma typing system based on IDH1-R132H and ATRX expression
  • Glioma typing system based on IDH1-R132H and ATRX expression

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Embodiment Construction

[0018] The present invention will be described in further detail below in conjunction with embodiment.

[0019] 1. Patient information and source of specimens

[0020] A total of 211 cases of glioma were enrolled in this study, all from the Glioma Treatment Center of Beijing Tiantan Hospital. All patients received surgical resection, radiotherapy and alkylating agent treatment from January 2008 to March 2015, and the postoperative pathological diagnosis was glioma (according to the 2007 WHO classification criteria for tumors of the central nervous system).

[0021] Among all patients, there were 112 males and 99 females, aged 16-69 years, with an average (40) years old. The study was approved by the Ethics Committee of the relevant unit and the patients signed the informed consent.

[0022] 2. Paraffin embedding of tumor tissue

[0023] 2.1 Main instruments and reagents

[0024] Paraffin embedding machine: manufacturer: Hao Silin; product number: TEC2800

[0025] Milli-Q ...

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Abstract

The invention relates to a glioma typing system based on IDH1-R132H and ATRX expression. The system comprises: (1) glioma patients' tumor paraffin embedding kit and optional kit application instruction; (2) a kit for immunohistochemical detection of ATRX protein expression level of tumor of glioma patients and optional kit application instruction; and (3) a kit for immunohistochemical detection of IDH1-R132H protein expression in tumor of glioma patients and optional kit application instruction. When IDH1-R132H and ATRX losses are combined as diagnostic markers for distinguishing primary glioblastoma, WHO grading II / III oligodendroglioma, WHO grading II / III astrocytoma and secondary glioblastoma, diagnostic specificity is obviously higher than diagnostic specificity of the two single markers of IDH1-R132H or ATRX losses.

Description

technical field [0001] The invention relates to the field of disease typing, in particular to a glioma typing system based on IDH1-R132H and ATRX. Background technique [0002] According to the WHO classification, diffuse gliomas are divided into grade II, grade III, and astrocytic glioma of glioblastoma, oligoastroglioma, and oligodendroglioma. Patients with lower-grade gliomas (LGGs, grade II) have a more favorable prognosis than patients with high-grade gliomas (grades III and IV), and in 50-75% of patients with low-grade gliomas, tumor Continues to grow and develop into higher levels, leading to neurological disease and eventual death. [0003] Astrocytoma is the most common pathological type of brain tumor, which is very prone to recurrence or malignant progression, and is difficult to cure even after surgery, radiotherapy and chemotherapy. Malignant astrocytomas such as glioblastoma are the deadliest intracranial tumors. The prognosis of patients with astrocytoma de...

Claims

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57484G01N2800/56
Inventor 江涛蒋传路蔡金全
Owner 江涛
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