How a quadrupole mass analyzer works

A technology for mass analyzers and working methods, applied in mass spectrometers, particle separation tubes, trajectory-stabilized spectrometers, etc., can solve the problems of insufficient abundance sensitivity, time-consuming and labor-intensive, low resolution of quadrupole mass analyzers, etc., to achieve The effect of improving abundance sensitivity and ensuring accuracy

Active Publication Date: 2017-11-17
HANGZHOU PUYU TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Quadrupole mass analyzers are low-resolution mass spectrometers, generally only able to achieve unit mass resolution
[0003] At present, the abundance sensitivity index of ICP-MS is generally between 0.1ppm and 1ppm, which cannot meet the requirements for some special occasions, and can only be reduced by optimizing the analysis method, such as increasing matrix separation in sample pretreatment. Influenced by the degree of sensitivity, this method increases the difficulty of sample pretreatment, making sample pretreatment complex and cumbersome, time-consuming and laborious
In addition, for samples with large differences in element concentration and isotopes with large differences in abundance ratio, the abundance sensitivity determines the accuracy of sample analysis, and the accuracy and reliability of the analysis results cannot be guaranteed if the abundance sensitivity is insufficient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This embodiment provides a working method of a quadrupole mass analyzer, including applying RF voltage and DC voltage on the quadrupole mass analyzer, and the working method also includes:

[0025] A frequency mixing signal is applied to the quadrupole mass analyzer, and the frequency mixing signal makes the ions to be isolated resonate.

[0026] Further, a frequency mixing signal is applied to the opposite electrode of the quadrupole mass analyzer.

[0027] Preferably, a frequency mixing signal is applied to a pair of opposite electrodes of the quadrupole mass analyzer.

[0028] After applying the mixing signal on the quadrupole mass analyzer, the ions to be isolated collide with the quadrupole, and the ions to be screened pass through the quadrupole mass analyzer. The frequency mixing signal is the oscillation frequency of the ion to be isolated or a mixture of a series of frequencies close to the oscillation frequency. The ion to be isolated resonates and oscillates...

Embodiment 2

[0041] Application of the working method of the quadrupole mass analyzer in Example 1 of the present invention in ICP-MS. In this application example, the mass number of the ion to be screened is m 0 , the width of the isolation window is Δm (Δm is set according to actual needs, such as 1, 2, etc.), and the mass numbers of the ions to be isolated on both sides of the isolation window are m 1 and m 2 , ie m 1 with m 2 The difference is Δm, which can make

[0042] The workflow of the quadrupole mass analyzer in ICP-MS is as follows:

[0043] S1. Obtain the frequency of the ion to be isolated:

[0044] According to the relation: and It can be seen that the a value and q value at the same moment are inversely proportional to the mass number, and ions with different mass numbers correspond to different a and q values, that is, m 1 The corresponding a and q are a 1 and q 1 , m 2 The corresponding a and q are a 2 and q 2 ; Then according to the relationship between t...

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PUM

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Abstract

The invention relates to a working method of a quadrupole rod mass analyzer. The working method comprises the step of applying RF voltage and DC voltage onto the quadrupole rod mass analyzer and also comprises the step of applying a hybrid frequency signal on the quadrupole rod mass analyzer, the hybrid frequency signal allows ions to be isolated to generate resonance, the ions to be isolated crashes with a quadrupole rod, and the irons to be screened pass through the quadrupole rod mass analyzer. The working method has the advantages of high abundance sensitivity, accurate and reliable analysis result and the like.

Description

technical field [0001] The invention relates to the field of elemental analysis, in particular to a working method of a quadrupole mass analyzer applied to ICP-MS. Background technique [0002] Quadrupole mass analyzer is one of the most mature mass analyzers, and it is widely used in GC-MS, LC-MS and ICP-MS. Quadrupole mass analyzers are low-resolution mass spectrometers, and generally can only achieve unit mass resolution. However, in the application of ICP-MS, the concentration of each element in the sample to be analyzed varies greatly, and the isotopic abundance ratio of some elements also varies greatly. The low resolution of the quadrupole mass analyzer makes the high concentration ion pair The ionic strength of the surrounding mass can produce strong interference, especially when the surrounding mass element concentration is very low for ultratrace analysis or the surrounding mass isotope abundance is very low for isotope ratio measurement. Therefore, the quadrupol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/42
CPCH01J49/4275
Inventor 梁炎韩双来刘立鹏俞晓峰郑毅
Owner HANGZHOU PUYU TECH DEV CO LTD
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