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Compound and preparation method thereof

A technology of compounds and base catalysts, applied in the field of active compounds and their preparation, can solve problems such as inability to meet the needs of medicines, and achieve the effects of reducing toxicity and achieving good effects

Inactive Publication Date: 2016-05-11
BEIJING YISHENGTANG MEDICAL TECH RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, with the evolution of diseases, problems such as virus resistance and body drug resistance, new drugs developed simply by relying on certain medicinal plants or the components contained in medicinal plants as precursors are far from satisfying people's expectations for drugs. needs

Method used

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  • Compound and preparation method thereof
  • Compound and preparation method thereof
  • Compound and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0048] An embodiment of the compound of the present invention, the chemical structural formula of the compound described in this embodiment is as attached figure 1 As shown, the compound described in this example is prepared by the following preparation method:

[0049] (1) Place the compound of formula (6) in a dry and clean three-necked flask, add HEPT, the molar ratio of HEPT to the compound of formula (5) is 5:1, heat and reflux reaction in the electric jacket, at a temperature of 50- The reaction was carried out at 400°C, monitored by HPLC during the reaction, and the reaction was stopped until the basic reaction of the raw materials was complete or the product no longer increased. When the temperature drops below 120°C, add pure ice water while stirring, place it in the refrigerator for crystallization (at a temperature of about 0°C), suction filter, wash, and dry after crystallization to obtain the formula (1) Compound; In this step, the yield of the compound of the ob...

Embodiment 2

[0054] An embodiment of the compound of the present invention, the chemical structural formula of the compound described in this embodiment is as attached figure 1 As shown, the compound described in this example is prepared by the following preparation method:

[0055] (1) Place the compound of formula (6) in a dry and clean three-necked flask, add DMAC, the molar ratio of DMAC to the compound of formula (5) is 6:1, and heat the reflux reaction in the electric jacket, at a temperature of 50 ~ The reaction was carried out at 400°C, monitored by HPLC during the reaction, and the reaction was stopped until the basic reaction of the raw materials was complete or the product no longer increased. When the temperature drops below 120°C, add pure ice water while stirring, place it in the refrigerator for static crystallization (at a temperature of about 0°C), filter with suction after crystallization, wash, and dry to obtain the formula (1) Compound; In this step, the yield of the c...

Embodiment 3

[0059] An embodiment of the compound of the present invention, the chemical structural formula of the compound described in this embodiment is as attached figure 1 As shown, the compound described in this example is prepared by the following preparation method:

[0060] (1) Place the compound of formula (6) in a dry and clean three-necked flask, add DMSO, the molar ratio of DMSO to the compound of formula (5) is 8:1, heat and reflux reaction in the electric jacket, at a temperature of 50 ~ The reaction was carried out at 400°C, monitored by HPLC during the reaction, and the reaction was stopped until the basic reaction of the raw materials was complete or the product no longer increased. When the temperature drops below 120°C, add pure ice water while stirring, place it in the refrigerator for crystallization (at a temperature of about 0°C), suction filter, wash, and dry after crystallization to obtain the formula (1) Compound; In this step, the yield of the compound of the o...

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Abstract

The invention discloses a compound. The compound is prepared from berberrubine and magnolol through two times of nucleophilic substitution reactions under certain conditions. According to the compound, the inventor is guided by the traditional Chinese medicine pair theory and the traditional Chinese medicine clinical medication experience, berberrubine and magnolol are purposefully and selectively combined through a specific synthetic method, and the obtained compound has the effects of increasing the effect and reducing toxins, and has better effects on the aspects of inflammatory resisting, tumor resisting, cancer resisting, hyperglycemia and hyperlipidemia reducing, bacterium resisting, cardiovascular and cerebrovascular disease resisting and the like. Meanwhile, the invention discloses a preparation method of the compound and application of the compound in preparing medicine for treating tumors, cancer, hyperglycemia, hyperlipidemia and the cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a compound and a preparation method thereof, in particular to a compound with anti-inflammatory, anti-tumor, hypoglycemic and lipid-lowering, antibacterial and other effects and a preparation method thereof. Background technique [0002] Today, with the development of modern pharmacology, molecular biology and other theories and related science and technology, the ways and means of natural medicine development are constantly innovating. At present, there are roughly three ways to develop new drugs, namely the folk medicine way, the experience medicine way and the molecular way. Among them, with the development of molecular biology, genetics and information processing technology, molecular pathway has gradually become the main way to develop new drugs. However, based on the current national conditions of our country, and due to the limitations of technical equipment, at present, folk medicine and empirical medicine are the main...

Claims

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Application Information

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IPC IPC(8): C07D519/00C07D455/03A61P35/00A61P35/02A61P3/10A61P3/06A61P9/00A61P9/10A61P29/00A61P31/04A61P31/10
CPCC07D519/00C07D455/03
Inventor 李卫民冯毅凡朱贺年李铀张志朋
Owner BEIJING YISHENGTANG MEDICAL TECH RES CO LTD
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