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Application of neural stem cells in mediator influenced expression of protein P25 and P35

A technology for neural stem cells and protein expression, which is used in nervous system diseases, medical preparations containing active ingredients, cardiovascular system diseases, etc.

Inactive Publication Date: 2016-05-11
SONGSHAN LAKE PEARL LAB ANIMAL SCI & TECH CO LTD DONGGUAN
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there are no effective treatments for brain injury and neurodegenerative diseases

Method used

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  • Application of neural stem cells in mediator influenced expression of protein P25 and P35
  • Application of neural stem cells in mediator influenced expression of protein P25 and P35
  • Application of neural stem cells in mediator influenced expression of protein P25 and P35

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Experimental program
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Effect test

Embodiment 1

[0032] 1. Experimental animals and groups:

[0033] Select 60 7-day-old SD rats, half male and half male, weighing 50-60 g, provided by the Experimental Animal Center of Southern Medical University (SYXK (Guangdong) 2011-0074), and divided into 3 groups according to the random number table method:

[0034] (1) HIE+PBS group (ischemia group): 20 rats, PBS was used as placebo treatment after successful HIE modeling;

[0035] (2) SHAM group (control group): 20 rats were only given sham surgery according to the HIE model making process, and no other intervention was given;

[0036] (3) HIE+NSC group (treatment group): 20 rats were treated with NSC after successful HIE modeling.

[0037] 2. Main equipment and reagents

[0038] (1) Main instruments: Rotarod (Rotarod, Jinan Yiyan Technology Development Co., Ltd., YLS-4C); RD1101-MWM-G MORRIS Water Maze Video Analysis System (Shanghai Yishu Information Technology Co., Ltd.); Haili Fu HF-240 automatic biochemical analyzer; stereotax...

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Abstract

The invention relates to an application of neural stem cells in mediator influenced expression of protein P25 and P35, and discloses an application of neural stem cells in the preparation of P24 and / or P35 protein expression regulating agents, and an application of neural stem cells in the preparation of drugs for treating hypoxic-ischemic encephalopathy or neurodegenerative diseases. The research results show that neural stem cells (NSC) can modulate the expression change of P25 and P35 protein. The NSC can increase the P35 protein expression, reduce the P25 protein expression, and inhibit the excessive activation of Cdk5, thus protects and treats the brain damage, and has a prominent effect on diseases such as hypoxic-ischemic encephalopathy. A novel method and drug are provided for the brain damage diseases (HIE, etc.) and neurodegenerative diseases.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of neural stem cells in mediating the expression of P25 and P35 proteins to promote the recovery of neurological function in newborn rats with ischemic-hypoxic encephalopathy. Background technique [0002] Hypoxic-ischemic encephalopathy (HIE) caused by perinatal asphyxia (hypoxic-ischemic encephalopathy, HIE) is a common brain injury disease. Phylogenetic disorders. According to statistics, the incidence of HIE in newborns in my country is about 3‰-6‰ of live births, of which 15%-20% die in the neonatal period, and 20%-30% of survivors may have neurological sequelae of varying degrees. In addition, there are various neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, etc., which have seriously threatened human health. [0003] So far, there are no effective treatments for brain injur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/30A61P9/10A61P25/00A61P25/28
CPCA61K35/30
Inventor 田雨光顾为望王玉珏吴清洪徐名衬
Owner SONGSHAN LAKE PEARL LAB ANIMAL SCI & TECH CO LTD DONGGUAN
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