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Dynamic intensity-modulated radiotherapy method based on quadratic programming model suppressing total beam-out time

A technology of secondary planning and intensity-modulated radiotherapy, which is used in radiotherapy, treatment and other directions to achieve the effect of eliminating convex and groove effects, overcoming blade wear, and overcoming inaccurate positioning.

Inactive Publication Date: 2016-04-13
NANYANG NORMAL UNIV
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For the various requirements, constraints and variables that need to be considered in the process of obtainin

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  • Dynamic intensity-modulated radiotherapy method based on quadratic programming model suppressing total beam-out time
  • Dynamic intensity-modulated radiotherapy method based on quadratic programming model suppressing total beam-out time
  • Dynamic intensity-modulated radiotherapy method based on quadratic programming model suppressing total beam-out time

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Embodiment Construction

[0040] Such as figure 1 As shown, the overall workflow of the reverse planning of dynamic intensity-modulated radiotherapy based on the multi-leaf collimator mainly includes the acquisition of the 3D medical image of the area to be treated and the outline of the target area, the simulation calculation of the radiation dose in the tissue area to be treated, and the multi-leaf collimator-based Inverse optimization of dynamic intensity-modulated radiotherapy for straighteners, simulation evaluation of optimization results, output of blade drive files and execution of dose modulation, etc.

[0041] Since the convex programming model is adopted, the algorithm of the optimization process is deterministic, so the most important step in the reverse optimization of dynamic intensity-modulated radiotherapy involved in the present invention is the establishment of a mathematical model, that is, to determine the input of the model. The input conditions include delineation and determinatio...

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Abstract

The invention discloses a dynamic intensity-modulated radiotherapy method based on a quadratic programming model suppressing total beam-out time. The method comprises: modeling according to a clinical dose target and constraints; mathematically describing a radiation field intensity pattern through front-drive and rear-drive blade movement matrixes, and on such basis, establishing convex programming conditions with upper and lower blade collision constraints and typical blade tongue-and-groove effect constraints; establishing corresponding convex programming conditions by analyzing a relation between blade movement speed and total beam-out time and the blade movement matrixes; finally, with respect to the defects that blade unidirectional movement modulation doses are limited and blades are abraded by random reciprocating motion, establishing a blade bidirectional movement mode. The dynamic intensity-modulated radiotherapy method that can meet most clinical implementation software-hardware constraints and needs is successfully obtained. The dynamic intensity-modulated radiotherapy method can be directly used for mathematical modeling and solving of volumetric modulated arc therapy after the radiation field angle is raised to a certain amount.

Description

technical field [0001] The invention belongs to the technical field of radiation therapy mathematical programming, and relates to a method for obtaining a reverse plan of intensity-modulated radiotherapy, in particular to an optimization method for a multi-leaf collimator to realize a reverse plan of dynamic intensity-modulated radiotherapy. Background technique [0002] At present, the most important treatment methods for malignant tumors include surgery, chemotherapy and radiation therapy, especially for advanced cancer cases, radiation therapy accounts for a large proportion; and among the radiation therapy methods, nearly 20 One of the most widely used treatment methods at home and abroad in 2009 is intensity-modulated radiotherapy, that is, the dimension of adjustable intensity is added to conformal radiotherapy. [0003] Major manufacturers of intensity-modulated radiotherapy equipment in the world include Varian, Elekta, Philips, Siemens and other companies. The IMRT...

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Application Information

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IPC IPC(8): A61N5/00
CPCA61N5/00
Inventor 兰义华贾晓张建洋张丽娜赵莉栗方王骁力王旸宋晓
Owner NANYANG NORMAL UNIV
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