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Preparation method of modified starch styptic powder

A technology of hemostatic powder and starch, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of local heat release, non-degradable, easy allergies, etc., and achieve the effect of improving production efficiency and simplifying the production process

Inactive Publication Date: 2016-04-06
WUHAN HAIJIYA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although there are many hemostatic materials on the market, they all have the disadvantages of being prone to allergies, not easy to degrade, and local heat generation.

Method used

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  • Preparation method of modified starch styptic powder
  • Preparation method of modified starch styptic powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dissolve starch with a molecular weight of 5000 in water to prepare a solution with a mass concentration of 10%, gelatinize at 30°C for 200 minutes at a stirring speed of 100 rpm, and add starch with a mass ratio of 10:1 after the solution is uniformly mixed. Combined agent sodium trimetaphosphate, after continuing to stir for 5 hours, carry out spray drying, the air velocity of spray drying is 50 liters / minute, and gas temperature is 100 ℃. The spray-dried modified starch granules are collected to obtain hemostatic powder microspheres, and the particle diameter of the microspheres is 50-300 microns.

Embodiment 2

[0021] Dissolve starch with a molecular weight of 100,000 in water to make a solution with a mass concentration of 3%, gelatinize at 70°C for 100 minutes at a stirring speed of 6000rpm, and add starch with a mass ratio of 50:1 after the solution is evenly mixed. The cross-linking agent sodium hexametaphosphate was continued to be stirred for 3 hours and then spray-dried. The air velocity of the spray-dried air was 100 liters / minute, and the gas temperature was 150° C. The spray-dried modified starch granules are collected to obtain hemostatic powder microspheres, and the particle diameter of the microspheres is 5-100 microns.

Embodiment 3

[0023] Dissolve starch with a molecular weight of 3 million in water to make a solution with a mass concentration of 0.01%, gelatinize at 100°C for 10 minutes at a stirring speed of 3000rpm, and add starch with a mass ratio of 100:1 after the solution is evenly mixed. Cross-linking agent sodium trimetaphosphate, after continuing to stir for 0.5 hours, carry out spray drying, the air velocity of spray drying is 80 liters / minute, and gas temperature is 50 ℃. The spray-dried modified starch granules are collected to obtain hemostatic powder microspheres, and the particle diameter of the microspheres is 20-80 microns.

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Abstract

The invention provides a preparation method of modified starch styptic powder. The prepared modified starch styptic powder is starch microspheres modified through cross-linking. The preparation technology of the modified starch styptic powder comprises the steps that starch with the molecular weight ranging from 5,000 to 3 million is dissolved in water, the mass concentration ranges from 0.01% to 10%, gelatinization is conducted for 10-200 min at 30-100 DEG C at the stirring speed ranging from 100 rpm to 6,000 rpm, and after the solution is mixed to be uniform, a cross-linking agent is added, wherein the mass ratio of the cross-linking agent to the starch ranges from 100:1 to 10:1; stirring is continuously conducted for 0.5-5 h, spray drying is conducted, the airflow velocity of spray drying ranges from 1 L / min to 100 L / min, and the air temperature is 50-200 DEG C; modified starch particles subjected to spray drying are collected, and the modified starch styptic powder microspheres with the particle size ranging from 5 micrometers to 1,000 micrometers are obtained.

Description

technical field [0001] The invention relates to a preparation method of modified starch hemostatic powder, belonging to the field of biomedical polymer materials. Background technique [0002] In daily life, how to stop bleeding quickly and effectively is an urgent problem to be solved. Effective hemostasis in surgical operations can make the operation go smoothly, improve the success rate of the operation, and reduce postoperative complications; on the battlefield, effective hemostasis is one of the most effective measures to reduce casualties of soldiers one. [0003] Hemostatic materials have an important impact on reducing bleeding, shortening operation time and postoperative patients in various surgical operations. At present, although there are many hemostatic materials on the market, they all have the disadvantages of being prone to allergies, not easy to degrade, and local heat generation. Therefore, it is of great significance to develop new, safe and efficient h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44C08B31/00C08J3/12
Inventor 何斌李赛曹俊黄建华周湘汉刘萍董恩钊
Owner WUHAN HAIJIYA BIOTECH CO LTD
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