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Application of partial agonist of dopamine (DA) D2 receptor to preparation of drugs for inhibiting myopia and using method of partial agonist

A kind of agonist, dopamine technology, applied to the partial agonist of dopamine D2 receptor, the application field of preparing anti-myopia drugs, can solve the problem that there is no report on the effect of myopia, and achieve the effect of inhibiting experimental myopia in animals

Active Publication Date: 2016-03-30
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0005] So far there is no report on the effect of dopamine D2 receptor partial agonists on myopia

Method used

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  • Application of partial agonist of dopamine (DA) D2 receptor to preparation of drugs for inhibiting myopia and using method of partial agonist
  • Application of partial agonist of dopamine (DA) D2 receptor to preparation of drugs for inhibiting myopia and using method of partial agonist
  • Application of partial agonist of dopamine (DA) D2 receptor to preparation of drugs for inhibiting myopia and using method of partial agonist

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Embodiment Construction

[0016] The experimental animals were four-week-old C57BL / 6 mice. Monocular form deprivation (FDM) was performed around the eyes with hemispherical opaque plastic eyepatch, and the contralateral eye was the control eye. At the same time, different doses of Aripiprazole were injected intraperitoneally to form-deprived eyes every day. Animals were randomly divided into 4 groups: simple form deprivation group (FD), form deprivation vehicle group (FD-Vehi), form deprivation low dose group (FD-APZ-1, given Aripiprazole dose 1mg / kg / day), Form deprivation high-dose group (FD-APZ-10, given Aripiprazole dose 10±5mg / kg / day). The ocular biological parameters such as diopter, corneal curvature and eye axis were measured before and after the experiment.

[0017] Dissolve Aripiprazole in 20% dimethylformamide solution (DMF), adjust the pH to 5~6 with acetic acid, and dissolve it completely. After comprehensive consideration of the half effective dose of the drug and its specific biologica...

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Abstract

The invention provides an application of a partial agonist of a dopamine (DA) D2 receptor to preparation of drugs for inhibiting myopia and a using method of the partial agonist. The application and the using method have the beneficial effects that the functions of the DA D2 receptor in myopia are stabilized by applying the partial agonist aripiprazole of the DA D2 R; aripiprazole has the effect of inhibiting lengthening of vitreous cavities and oculi axes in the form deprivation myopia process, thus inhibiting formation of experimental myopia of animals.

Description

technical field [0001] The invention relates to the field of myopia treatment, in particular to the application of a partial agonist of dopamine D2 receptor in the preparation of myopia inhibiting medicine and its use method. Background technique [0002] Dopamine (dopamine, DA) is a neurotransmitter on the retina. We and our predecessors found that in animal experiments, the content of dopamine in the retina decreased during the formation of myopia, and then increased and returned to normal levels during the recovery period. The outcome of form deprivation myopia is highly consistent, suggesting that dopamine is involved in the formation of myopia. At the same time, the study found that apomorphine (APO), a non-selective agonist of dopamine receptors, can inhibit the progression of myopia in chickens and monkeys, further supporting the inhibitory effect of dopamine on the development of myopia. Epidemiological surveys in recent years have shown that outdoor activities can ...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61P27/10
CPCA61K31/496
Inventor 周翔天瞿佳黄芙蓉万芬
Owner WENZHOU MEDICAL UNIV
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