Bionic glomerulus chip and chipset composed of bionic glomerulus chips

Abstract

The invention discloses a bionic glomerulus chip. The chip is characterized in that a porous polycarbonate membrane layer is included, and an upper chip layer and a lower chip layer are fixed on the two faces of the polycarbonate membrane layer respectively and both made of polydimethylsiloxane; an upper inlet pool, a rectangular upper cell culture room and an upper outlet pool are thoroughly formed in the upper chip layer, a first channel is communicated between the upper inlet pool and the upper cell culture room, a second channel is communicated between the upper outlet pool and the upper cell culture room, the width of the first channel and the width of the upper cell culture room are both H, and the width of the second channel is h, wherein H:h=10:3; a lower inlet pool, a rectangular lower cell culture room and a lower outlet pool are thoroughly formed in the lower chip layer, a third channel is communicated between the lower inlet pool and the lower cell culture room, a fourth channel is communicated between the lower outlet pool and the lower cell culture room, and the width of the lower cell culture room, the width of the third channel, and the width of the fourth channel are all H.

Description

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AI Technical Summary

Benefits of technology

The technical effect of this new technology compared to previous designs was that it had better performance than older versions.

Problems solved by technology

This patented technology discusses various ways how can test renal functions by culturing isolated extracellu larves called MGCs and other small cells without damaging their membranous structure during experimentation. Existing techniques have limited applicability due to factors like lack of homogeneity among these cells and difficulties controllably deliver substances into specific locations within the tissue space being studied. Additionally, current experimental designs require complex equipment and involve multiple steps, making it challenged to replicate all aspects of the process overcomes shortcomings related to conventional approaches.

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