Method for measuring hexamidine, chlorhexidine, and salts thereof in cosmetics

A method of determination and technology of cosmetics, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of non-determined cosmetics detection methods, and achieve the effect of simple methods

Active Publication Date: 2016-03-09
CHINESE ACAD OF INSPECTION & QUARANTINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no detection method for the determination of hexamidine, chlorhexidine and their salts in cosmetics at home and abroad

Method used

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  • Method for measuring hexamidine, chlorhexidine, and salts thereof in cosmetics
  • Method for measuring hexamidine, chlorhexidine, and salts thereof in cosmetics
  • Method for measuring hexamidine, chlorhexidine, and salts thereof in cosmetics

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Experimental program
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Embodiment Construction

[0056] 1. Reagents and materials

[0057] Unless otherwise specified, the reagents used are of analytical grade, and the water is the first-grade water specified in GB / T6682.

[0058] Acetonitrile: chromatographically pure.

[0059] Methanol: chromatographically pure.

[0060] Tetrahydrofuran: chromatographically pure.

[0061] Trifluoroacetic acid: chromatographically pure.

[0062] Saturated sodium chloride solution: Weigh 40g of sodium chloride, put it in a 250mL Erlenmeyer flask, add 100mL of water, shake well, and sonicate for 10min.

[0063] The basic information and structural formulas of hexamidine, chlorhexidine and their salts are as follows.

[0064] Table 4 Basic information on hexamidine, chlorhexidine and their salts

[0065] compound

molecular formula

molecular weight

CAS number

hexamidine

C 20 h 26 N 4 o 2

354.4

3811-75-4

Hexamidine bis(isethionate) salt

C 20 h 26 N 4 o 2 2C 2 h 6 o 4 ...

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Abstract

The invention discloses a method for measuring hexamidine, chlorhexidine, and salts thereof in cosmetics. The method comprises the following steps: (1) preprocessing a cosmetic sample; (2) detecting the hexamidine, chlorhexidine, and salts thereof in the cosmetic sample through HPLC (high performance liquid chromatography); (3) drawing a standard curve, and calculating; (4) carrying out confirmatory tests by a LC(liquid chromatography)-MC(mass chromatography) / MC method. The provided method uses HPLC to synchronously measure hexamidine, chlorhexidine, and salts thereof in cosmetics, and is simple, convenient, rapid, and accurate. The detection limit, quantification limit, recovery rate, and precision of the method are all qualified.

Description

technical field [0001] The invention relates to a detection method of chemical substances, in particular to a detection method of hexamidine, chlorhexidine and their salts in cosmetics. Background technique [0002] Hexamidine and its salts are traditionally used as antifungal agents (the maximum allowable use concentration is 0.1%), cationic substances with broad-spectrum antibacterial and bactericidal properties, and have been used in cosmetics for a long time. Positive bacteria and negative bacteria, as well as various molds and yeasts have high bactericidal and bacteriostatic properties. Hexamidine bis(isethionate) salt is especially suitable for acne-removing cosmetics, and the addition amount is generally 0.08% to 0.1%. At the same time, because of its good compatibility and stability, it is almost suitable for various dosage forms. Almost all cosmetic formulations such as creams, serums and gels. In addition, hexamidine bis(isethionate) salt also inhibits the lipase...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88
Inventor 马强孟宪双白桦郭项雨
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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