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Apparatus, systems and methods for delivery of medication to the brain to treat neurological condidtions

A technology for delivering drugs and drugs, applied in the field of devices for treating neurological events or conditions, and devices for treating adverse neurological events or conditions, which can solve the problems of frequent replenishment of medicaments during shelf life, inappropriate medical applications, inapplicability, etc.

Inactive Publication Date: 2016-03-02
INCUBE LABS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the size and power requirements of currently available pumps, they are not suitable for all medical applications, especially for drug delivery to the brain where very precisely controlled doses of agents may be required (eg, for the treatment of various neurological conditions) are not applicable
Additionally, current devices may require frequent refills due to limited reservoir size and / or limited drug shelf life

Method used

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  • Apparatus, systems and methods for delivery of medication to the brain to treat neurological condidtions
  • Apparatus, systems and methods for delivery of medication to the brain to treat neurological condidtions
  • Apparatus, systems and methods for delivery of medication to the brain to treat neurological condidtions

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Embodiment Construction

[0073]Embodiments described herein provide systems, devices, and methods for detecting and treating various neurological events or conditions, such as epilepsy, migraine, depression, and various non-epileptic seizures, among others. Many embodiments provide for detection of abnormal activity, such as abnormal neural activity and / or cortical spreading depression (CSD), prior to the actual physical manifestation of the event or condition caused by the abnormal activity (e.g., during a seizure, migraine, or other neurological Devices and methods for detecting electrical activity and / or CSD prior to the occurrence of an event or condition and then using this information to initiate drug delivery to prevent or reduce the duration of seizures or other neurological events. Certain embodiments provide devices and methods for treating epilepsy and other neurological conditions by delivering solid form drugs to one or more ventricles or other regions of the brain. Particular embodiments...

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PUM

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Abstract

Various embodiments provide an apparatus, system method for treating neurological conditions by delivering solid form medication to the ventricles or other areas of the brain. Particular embodiments provide an apparatus and method for treating epilepsy and other neurological conditions by delivering solid form medication to ventricles in the brain wherein the medication is contained in a diffusion chamber so as to allow the medication to dissolve in the cerebrospinal fluid of the brain and then diffuse out of the diffusion chamber to be delivered to the ventricles and brain tissue. In one or more embodiments, portions of apparatus have sufficient flexibility to conform to the shape of the ventricles of the brain when advanced into them and / or to not cause deformation of the ventricle sufficient to cause a significant physiologic effect.

Description

[0001] cross reference [0002] This application claims the benefit of US Patent Application Serial No. 13 / 827,468, filed March 14, 2013, the entire disclosure of which is hereby incorporated by reference. [0003] The subject matter of this application is identical to U.S. Patent Application Serial No. 13 / 301,584, filed November 11, 2011, which is U.S. Patent Application Serial No. 12 / 359,830, filed January 26, 2009, entitled "Apparatus and Method for the Detection of Aberrant Neuro-Electric Activity" ( 8,374,703), and is also related to the subject matter of U.S. Application Serial No. 13 / 681,825 (Attorney Docket No. 42197-730.201), entitled "Myocardial Drug Delivery Apparatus and Method," filed November 20, 2012. subject matter, the entire disclosures of the aforementioned documents are hereby incorporated by reference. field of invention [0004] Embodiments described herein relate to devices, systems, and methods for treating adverse neurological events or conditions. ...

Claims

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Application Information

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IPC IPC(8): A61M31/00
Inventor M·伊姆兰菲利普·摩根本·特兰奇纳保罗·斯菲尔凯尔·霍伦
Owner INCUBE LABS
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