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System for breath sample collection and analysis

A technology for collecting systems and samples, used in respirators, analyzing materials, sampling, etc., and can solve problems such as high trauma

Inactive Publication Date: 2016-02-17
DETANG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current methods of obtaining samples from the lower respiratory tract such as transtracheal aspiration, bronchoalveolar lavage, and lung biopsy are highly invasive

Method used

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  • System for breath sample collection and analysis
  • System for breath sample collection and analysis
  • System for breath sample collection and analysis

Examples

Experimental program
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Effect test

example 1

[0115] Example 1: Exemplary Embodiment of a Sample Collection System

[0116] Figure 13 One embodiment of a sample collection system combining aspects is shown. The sample collection system (109) consists of a pre-collection assembly (108) and a collector (110). The pre-collection components are included in Figure 10c The mechanism for manipulating the flow from the patient is depicted in the embodiment shown in . Additionally, in these embodiments, the pre-collection assembly includes a mechanism for rejecting droplets larger than 10 μm with an efficiency greater than 50% as shown in FIG. 11 . In this embodiment, the pre-collection assembly consists of a T-joint (112) having three ends (114, 116, 118), wherein one end is connected to the mouthpiece (114) and the second end is connected to bag (116), while the third end is connected to the collector (118), but in Figure 13 Bag and mouthpiece not shown. In addition, the presented pre-collection assembly includes a one-...

example 2

[0117] Example 2: Improvements to the Fennelly collection system

[0118] The exemplary sample collection system described above can be contrasted with the Andersen impactor used in the Fennelly collection system, developed in 1958 for environmental sampling, which, while good at collecting bioaerosols, was not designed for use in Diagnostic testing of clinical samples. In particular, it has been shown that depositing bacteria on selective media such as 7H11 agar causes structural damage to the cells and can render up to 99% inactive (see e.g. Stewart et al., Applied and Environment Microbiology, 61(4): 1232- 1239, 1995, the disclosure of which is incorporated herein by reference). Furthermore, efficient extraction of PCR-ready DNA is impractical due to the large area of ​​the agar plate. Finally, the device was designed for research use, but was impractical for clinical use; the impactor was placed in a large (approximately 20" x 8") metal chamber that hindered delivery and...

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Abstract

Systems and methods for collecting samples from a patient for diagnosis are provided. In many embodiments, the sample collection and analysis system concentrates particles emanating from a patient's cough, sneeze, or breathe in a sample for the diagnosis of a respiratory tract infection or other ailment of the patient. The sample collection and analysis system has a pre-collection assembly (that is patient interface), a collector in fluid communication with a sample reservoir that function in combination to: efficiently capture the volume of air expelled from the subject, direct the expelled air towards a sample reservoir, and separate the desired particle sizes from the expelled air into the sample reservoir.

Description

technical field [0001] The present invention relates to a system for collecting and analyzing bacteria or biological particles; and more particularly to a system comprising an aerosol collection system for the detection of airborne bacteria or biological particles, the aerosol collecting The system can be used to prepare samples for diagnosis or can be used to directly diagnose bacterial infection samples from the environment or from patients such as tuberculosis patients. Background technique [0002] There are currently many challenges in collecting quality samples for the diagnosis of respiratory diseases. These challenges vary slightly across disease states, but common themes emerge. For example, tuberculosis, influenza, and pneumonia are three diseases that each represent specific diagnostic challenges. [0003] Active tuberculosis (TB) kills approximately two million people each year, making it the second leading cause of death from infectious diseases worldwide. Wo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/06C12N1/20C12Q1/68G01N1/22G01N33/497
CPCC12N1/06G01N33/497G01N1/2202G01N2001/2244A61B10/0051A61B10/00A61B2010/0083A61B2010/0087A61B5/082A61B5/097A61M16/085A61M16/201A61M16/105A61M16/208A61M2205/0216A61M2205/123A61M2205/58A61M2205/7545
Inventor P·希思利安R·纳斯尔L·鲁赫德S·A·查普曼
Owner DETANG CO LTD
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