Biological tissue photoacoustic circulating tumor cell detection and diagnosis device and method

Abstract

The invention discloses a biological tissue photoacoustic circulating tumor cell detection and diagnosis device. The device is provided with a high-frequency pulse laser, a microscope and a ultrasonic probe, and a detected object is arranged between the microscope and the ultrasonic probe so that laser generated by the high-frequency pulse laser can be focused on the detected object through the microscope. The invention further discloses a detection and diagnosis method of the detection and diagnosis device. Due to the adoption of the technical scheme, the defect that fluorescent markers interfere in the biological tissue physiological environment and have cytotoxicity on normal blood cells and lymphocytes is overcome. Non-invasive detection is achieved, haemospasia is avoided, and marking is not needed; data difference between animal individuals is avoided, and the number of animals needed during an animal experiment is greatly reduced; the application range is wide, and the biological tissue photoacoustic circulating tumor cell detection and diagnosis device can be widely applied to the immunology, hematology, oncology, cytobiology, cytogenetics, biochemistry, clinical medicine and basic medicine research fields; the device is simple in structure, convenient to operate and high in safety.

Description

technical field [0001] The invention belongs to the technical field of medical scientific research and diagnostic equipment. More specifically, the present invention relates to a biological tissue photoacoustic circulating tumor cell detection and diagnosis device. The invention also relates to a detection and diagnosis method applied to the detection and diagnosis device. Background technique [0002] Cancer is a disease that seriously threatens human health and life. If cancer patients can be detected and treated in time, not only the survival rate can be improved, but also the quality of life of patients can be improved. Therefore, early detection, early diagnosis and timely treatment of cancer are necessary. [0003] In recent years, the development of optical early diagnosis technology for cancer, including photoacoustic imaging, photoacoustic tomography, photoacoustic spectral microscopy imaging, etc. For example, flow cytometry detection technologies mainly include ...

AI Technical Summary

Problems solved by technology

Fluorescent markers are cytotoxic and need to be injected intravenously or sampled after in vitro staining, which causes tissue trauma and may affect the physiological environment of cells in vivo. It is

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