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Pig pseudorabies live vaccine-pig mycoplasma pneumonia live vaccine composition and application thereof

A technology for mycoplasma suis pneumonia and porcine pseudorabies disease, which can be used in drug combinations, antiviral agents, bacterial antigen components, etc., and can solve problems such as titer decline

Active Publication Date: 2016-02-03
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a combination of porcine pseudorabies live vaccine-mycoplasma swine pneumonia live vaccine, to solve the problem of continuous stress of the two vaccines respectively immunizing the vaccinated animals, and to avoid the long-term contact of the two antigen components of the joint vaccine. reduce the risk of falling prices, while simplifying the immunization procedures

Method used

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  • Pig pseudorabies live vaccine-pig mycoplasma pneumonia live vaccine composition and application thereof
  • Pig pseudorabies live vaccine-pig mycoplasma pneumonia live vaccine composition and application thereof
  • Pig pseudorabies live vaccine-pig mycoplasma pneumonia live vaccine composition and application thereof

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Embodiment Construction

[0013] The combination of the present invention includes a live vaccine of porcine pseudorabies, a live vaccine of Mycoplasma suis pneumonia and a vaccine dilution. in:

[0014] 1. Porcine pseudorabies live vaccine, inoculated chicken embryo fibroblasts with attenuated porcine pseudorabies virus strain (Bartha-K61 strain), harvested cell culture, added suitable freeze-drying protective agent, and prepared by freeze-vacuum drying.

[0015] 2. Mycoplasma hyopneumoniae pneumonia live vaccine is inoculated with Mycoplasma hyopneumoniae (RM48 strain) for culture, and the culture is harvested, added with suitable freeze-drying protective agent, and made by freeze-vacuum drying.

[0016] 3. Diluent, the main component is diluent of PBS or physiological saline.

[0017] 4. Dilute the live porcine pseudorabies vaccine with diluent or normal saline whose main component is PBS, and dilute it to contain 1 live porcine pseudorabies vaccine per 0.5mL, and dilute the live vaccine of Mycopla...

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Abstract

The invention relates to a pig pseudorabies live vaccine-pig mycoplasma pneumonia live vaccine composition and the application thereof. When the vaccine composition is applied to immune animals, two vaccines can be obtained to achieve different immune effects, continuous stress on inoculated animals caused by independent immunity can be avoided, immune procedures are simplified, and immunization workload is reduced for a pig farm.

Description

technical field [0001] The invention relates to a porcine pseudorabies-Mycoplasma suis pneumonia live vaccine combination, which belongs to the field of veterinary biological products. Background technique [0002] Porcine pseudorabies (Pseudorabies, PR) is a highly contagious infectious disease caused by pseudorabies virus (Pseudorabiesvirus, PRV), which can cause reproductive disorders in breeding pigs, piglets respiratory syndrome, neurological symptoms, diarrhea, growth retardation and other main symptoms At the same time, PRV is also one of the important primary pathogens causing porcine respiratory disease syndrome (SARAHG, HERMANWF, LENNERTS, et al. Atrypsin-likeserineproteaseisinvolvedinpseudorabiesvirusinvasionthroughthebasementmembranebarrierofporcinenasalrespiratorymucosa.VetRes, 2011, 42(4):79-83.) (LAURENCEF, CLAIRERG , MARIELLEC, et al. Transcriptomic analysis of the dialogue between Pseudorabies virus and porcine epithelial cells during infection. BMC Genomics...

Claims

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Application Information

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IPC IPC(8): A61K39/245A61K39/02A61P31/22A61P11/00A61P31/04
Inventor 王蕾魏联果周忠涛孙旭燕李营张丹董海曼徐龙涛张广杨健
Owner QILU ANIMAL HEALTH PROD
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