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Mouse water maze learning and memory test platform

A technology of learning memory and testing platform, which is applied in application, animal taming device, animal husbandry, etc.

Inactive Publication Date: 2016-01-27
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the multi-arm water maze of the present invention can determine the degree of difficulty of the learning and memory water maze experiment according to the number of swimming arms, which is difficult to achieve in the common Morris water maze experiment design.

Method used

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  • Mouse water maze learning and memory test platform
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  • Mouse water maze learning and memory test platform

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The mouse water maze learning and memory test platform of the present invention combines the multi-arm maze with the Morris water maze to provide a multi-arm water maze test platform, including a dividing arm, a swimming pool b, and the dividing arm is placed in the swimming pool b, An escape platform a is arranged under the water surface at the end of one of the separating arms.

[0036] Wherein the spacer arm is 3, 4, 5 or 6 arm type;

[0037] wherein said swimming pool is a Morris circular swimming pool;

[0038] Wherein the arm length of each spacer arm is the same, the arm width is the same, and the arm height is the same;

[0039] Wherein the angle between each two spacer arms is the same;

[0040] Wherein said separating arm is made of transparent plexiglass, and each separating arm has an arm length of 40-50cm, an arm width of 15-20cm, and an arm height of 25cm;

[0041] The present invention is characterized in that: according to the needs of experiments, 3-6 ...

Embodiment 2

[0045] The fixed-position escape platform method (Reference memory) was used to evaluate the effect of the multi-armed water maze on the learning and memory ability of normal animals with reference memory. In this experiment, a water maze group with 3 to 6 arms was designed.

[0046] The experiment was carried out for 7 days. Among them, learning and training were carried out on 6 days: the escape platform was fixed on the A arm, and the memory test was carried out on the last day, that is, the 7th day: the escape platform was removed at this time. The EthoVision system (Netherlands, Noldus Company) was used to observe and record the animal swimming track.

[0047] Experimental animals: take 48 mice and divide them into five groups: three-arm water maze group: 9; four-arm water maze group: 9; five-arm water maze group: 10; six-arm water maze group: 10 ; Ordinary water maze group (circular, without arms): 10 rats.

[0048] Learning and training: Each animal was given 4 tra...

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Abstract

The invention relates to a mouse water maze learning and memory test platform, and belongs to the field of animal experiment instruments. According to the mouse water maze learning and memory test platform, a multi-arm maze is combined with a Morris water maze, and a multi-arm water maze test platform is provided. The mouse water maze learning and memory test platform comprises separation arms and a swimming pool, wherein the separation arms are placed inside the swimming pool, and an escape platform is arranged below the water surface of the tail end of each separation arm; and the separation arms are of a 3-6 arm type. The multi-arm water maze can determine the difficulty level of a water maze learning and memory experiment according to the number of increased swimming arms, and overcomes a technical problem that a common Morris water maze experiment design is difficult to be achieved. The mouse water maze learning and memory test platform can solve a phenomenon that a mouse floats on the water surface and does not move or swim of a common Morris water maze experiment to a great extent.

Description

technical field [0001] The invention relates to a mouse water maze learning and memory testing platform, which belongs to the field of animal experiment instruments. Background technique [0002] Since British scientists MorrisRG et al. (MorrisRG, GarrudP, RawlinsJN, O'KeefeJ. [0003] (1982) Placenavigationimpairedinratswithhippocampallesions.Nature, 297:681-683) first invented the use of water maze to study the learning and memory behavior of rodents in 1982, animal water maze experiments have been widely used in neurobiology, medicine, pharmacology, etc. field of research. Ordinary Morris water maze (Morriswatermaze, MWM) is to inject water into the circular water maze, place an escape platform about 1.5cm below the level of a specific point, and put the experimental rats or mice into the water maze , observe and record the behavioral data such as the time, swimming distance, speed, orientation angle and strategy used by the rodents to find and climb the escape platform...

Claims

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Application Information

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IPC IPC(8): A01K15/02
CPCA01K15/027
Inventor 张维宁王佳王玉聪
Owner JIANGSU UNIV
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