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KIAA1217-RET fusion gene

A technology of KIAA1217-RET and fusion genes, applied in the field of genes, can solve the problems such as the unknown mechanism of thyroid cancer

Active Publication Date: 2016-01-20
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Although some gene changes associated with PTC have been found, the mechanism of some thyroid cancers is still unknown

Method used

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Embodiment Construction

[0040] The present invention is specifically described below by the embodiment, only for further illustrating the present invention, can not be interpreted as the limitation of protection scope of the present invention, the technical engineer of this field can make some non-essential improvements and improvements to the present invention according to the content of the above-mentioned invention Adjustment.

[0041] (1) Acquisition and screening of KIAA1217-RET fusion gene

[0042] 1 Sources of papillary thyroid carcinoma tissue specimens

[0043] 1.1 Specimen inclusion criteria

[0044]The samples were all from the surgical resection specimens of patients diagnosed with papillary thyroid carcinoma by the oncology department of our hospital, and all 20 patients had not received other medical interventions (such as radiotherapy and chemotherapy) before operation. Before the specimen collection, it was approved by the Hospital Ethics Committee, and the informed consent was sign...

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Abstract

The invention discloses a KIAA1217-RET fusion gene. The KIAA1217-RET fusion gene is formed by exons from number one to number eleven of a KIAA1217 gene and exons from number eight to number nineteen of an RET gene in a fusion mode, and the nucleotide sequence is shown in figure 1. Disclose of the fusion gene is favorable for further study of drive genetic modification not found in thyroid cancer, and the clinical pathological classification and treatment strategies of patients suffering from papillary thyroid carcinoma are optimized.

Description

technical field [0001] The invention belongs to the field of gene technology, and specifically refers to a KIAA1217-RET fusion gene. Background technique [0002] The incidence of thyroid cancer has more than tripled in the past 30 years, and its different tissue types and gene expression profiles have changed over time. All thyroid cancers, except medullary carcinomas, arise from the follicular cells that make up the single-cell epithelial layer of the thyroid. Papillary thyroid carcinoma (PapillaryThyroidCarcinoma, PTC) is the most common pathological type of malignant thyroid tumors. PTC is often curable, with a 5-year survival rate of approximately 95%. However, some PTCs dedifferentiate into aggressive, fatal thyroid cancers. The current main treatment options include surgery, thyroid anti-TSH hormone endocrine therapy, and radioactive iodine therapy (using the principle that thyroid follicular cells have a high affinity for iodine). [0003] Genetic changes in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/62C07K19/00
Inventor 张筱骅王瓯晨陈恩东张玮周毅力曾瑞超金浪平蔡业丰董思洋张祥建王青煊扬帆刘叶欢薛丽君潘传孟
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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