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Use of 3,4-dihydroxybenzaldehyde to prepare medicines for treating or/and preventing cerebral ischemia-reperfusion injury

A technology of dihydroxybenzaldehyde and cerebral ischemia-reperfusion, which is applied in the field of medicine and achieves the effects of remarkable curative effect, inhibition of NO toxic reaction and low price

Active Publication Date: 2018-06-19
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far there is no public report about the pharmacological effects of 3,4-dihydroxybenzaldehyde on the prevention and treatment of cerebral ischemia-reperfusion injury

Method used

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  • Use of 3,4-dihydroxybenzaldehyde to prepare medicines for treating or/and preventing cerebral ischemia-reperfusion injury
  • Use of 3,4-dihydroxybenzaldehyde to prepare medicines for treating or/and preventing cerebral ischemia-reperfusion injury
  • Use of 3,4-dihydroxybenzaldehyde to prepare medicines for treating or/and preventing cerebral ischemia-reperfusion injury

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Embodiment Construction

[0034] The raw materials, reagents and equipment used in the specific embodiments of the present invention are all known products, obtained by purchasing commercially available products.

[0035] The beneficial effects of the present invention are demonstrated through experimental examples below.

[0036] 1. Experimental materials

[0037] 1.1 Experimental animals

[0038] Adult healthy male SD rats, weighing 250-300g, SPF grade, provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences, production license number: SCXK (Sichuan) 2008-24, certificate number: 0017670.

[0039] 1.2 Experimental drugs

[0040] 3,4-Dihydroxybenzaldehyde is a transparent solid crystal separated and purified from the EtOAc layer extract of Gastrodia elata by the Kunming Institute of Botany, Chinese Academy of Sciences. After the structure is confirmed, the monomer components purchased from Sigma Company in the United States are used in this experiment .

[0041] In ...

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Abstract

The invention discloses the use of 3,4-dihydroxybenzaldehyde for preparing medicine for treating or / and preventing cerebral ischemia-reperfusion injury. Pharmacodynamic experiments show that the compound has significant effects of protecting the blood-brain barrier, protecting nerve function and inhibiting the occurrence of NO toxicity, so as to achieve the effect of treating or / and preventing cerebral ischemia-reperfusion injury. Compared with the similar drugs and treatments commonly used in clinical practice at present, 3,4-dihydroxybenzaldehyde has a wide range of sources, low price, significant curative effect, and has a good clinical application prospect.

Description

technical field [0001] The invention relates to the application of 3,4-dihydroxybenzaldehyde in preparing medicines for treating or / and preventing cerebral ischemia-reperfusion injury, which belongs to the field of medicine. Background technique [0002] After cerebral ischemia restores blood supply for a certain period of time, its function not only fails to recover, but more serious brain dysfunction occurs, which is called cerebral ischemia-reperfusion (CIR) injury. At present, inhibiting reperfusion injury has become an important link in the treatment of ischemic cerebrovascular diseases. [0003] Cerebral ischemia-reperfusion injury is a complex pathophysiological process, which is mainly related to multiple mechanisms such as excessive formation of free radicals, toxic effects of excitatory amino acids, intracellular calcium overload, and inflammatory reactions. In recent years, research on the treatment of cerebral ischemia-reperfusion injury has achieved certain res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/11A61P9/10
Inventor 林青何芳雁代蓉李秀芳
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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