Application of Menin factor

A factor-response technology, applied in the application field of tumor suppressor Menin, can solve the problem that the role of pancreatic cancer has not been studied.

Active Publication Date: 2016-01-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, it is uncertain whether Menin factors are unregulated in pancreatic ductal adenocarcinomas,...

Method used

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Embodiment Construction

[0018] The specific implementation manners of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0019] In the following examples, the experimental methods for which specific experimental conditions are not indicated are usually in accordance with conventional conditions such as Smabrook et al., Molecular Cloning: The conditions described in the laboratory manual (New York: Cold Spring Harbor Laboratory Press, 1989), or according to the manufacturer's suggestion condition.

[0020] 1. Materials and methods

[0021] 1. Patient and tissue samples

[0022] Samples were collected from 64 patients who underwent surgery for pancreatic cancer between July 2010 and June 2012. Among these patients, the youngest was 35 years old, the oldest was 81 years old, and the average age wa...

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Abstract

The invention provides an application of a tumor inhibiting factor menin to diagnosis and treatment of pancreatic cancer. The mechanism that the menin factor inhibits growth of pancreatic cancer cells through overexpression is elaborated; on one hand, the menin factor inhibits growth of the pancreatic cancer cells by inhibiting expression of up-regulated genes p18, p27, HOXA9, HDAC5 and CBX4 and expression of down-regulated genes CDK2, CDK4, ESM1, IGFBP7 and GAS1; on the other hand, the menin factor is competitively combined with Dnmt1 to reduce the DNA methylation level of p18/p27 promoters and promotes transcription of p18/p27 genes to inhibit growth of the pancreatic cancer cells, and a new way is provided for treating the pancreatic cancer.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the application of a tumor suppressor Menin. Background technique [0002] Pancreatic cancer is currently known as a fatal cancer that seriously affects human health. Almost all patients with pancreatic cancer will face cancer cell metastasis, and finally die due to the uncontrollable growth of cancer cells. Therefore, understanding the pathogenesis of pancreatic cancer as well as the mechanism of development and prognosis is very important for the diagnosis, prevention and treatment of this disease. [0003] Similar to other malignant tumor diseases, pancreatic cancer is mainly caused by the accumulation of acquired mutations in genes, such as mutations in oncogenes, tumor suppressor genes, and genome maintenance genes. The mutation rates of individual tumor suppressor genes K-ras, p16, TP53, MADH4 and BRCA2 in pancreatic cancer were 85%, 82%, 76%, 53% and 10%, respect...

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Application Information

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IPC IPC(8): C12Q1/68G01N33/574A61K38/17A61P35/00
CPCA61K38/17C12Q1/6886G01N33/574
Inventor 程鹏金钢张怡杰李刚王云峰陈颖郝骏刘彻李森
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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