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Method for determining dose-effect of traditional Chinese medicine compound on basis of variable importance in projection

An importance and projection technology, which is applied in the field of determining the dose-response of traditional Chinese medicine compound prescriptions and giving clinical recommended dose thresholds based on variable importance projection analysis.

Active Publication Date: 2015-12-23
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional approach to clinician experience is not only individual but imprecise
When there are too many batches and ingredients of Chinese medicine, it is often difficult to give the exact dosage plan for the expected effect through the doctor's experience

Method used

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  • Method for determining dose-effect of traditional Chinese medicine compound on basis of variable importance in projection
  • Method for determining dose-effect of traditional Chinese medicine compound on basis of variable importance in projection
  • Method for determining dose-effect of traditional Chinese medicine compound on basis of variable importance in projection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A method for determining the dosage and effect of the whole prescription of Dachengqi Decoction based on variable importance projection analysis, the steps are as follows:

[0052] (1) VIP analysis of the variable projection importance index;

[0053] (1.1) Calculation method selection:

[0054] According to the experiment of Dachengqi Decoction entering the blood and drug efficacy indicators in the treatment of intestinal obstruction, inject the whole formula of Dachengqi Decoction into mice, observe the changes of the medicine in the blood, and determine the amount of change. In the prescription experiment, experts in traditional Chinese medicine provided 9 independent variables X and 3 dependent variables Y in the known experimental data. According to the Pearson correlation coefficient formula, the correlation coefficient between variables was calculated and drawn into a matrix correlation coefficient heatmap, see figure 1 ;

[0055] figure 1 Middle: The closer ...

Embodiment 2

[0107] A method for determining the dose-effect of the whole prescription of Gegen Qinlian Decoction based on variable importance projection analysis, the steps are as follows:

[0108] (1) Analysis of variable projection importance indicators;

[0109] (1.1) Calculation method selection:

[0110] According to the blood-entering components and efficacy indexes of Gegen Qinlian Decoction in the treatment of ulcerative colitis experiment, the whole prescription of Gegen Qinlian Decoction was injected into mice, and the changes of the medicine in the blood were observed to determine the changed amount. In the Gegen Qinlian Decoction whole recipe experiment, Chinese medicine experts provided 4 independent variables X and 5 dependent variables Y in the known experimental data, and the mutual correlation coefficient was calculated according to the Pearson correlation coefficient formula and plotted as a matrix correlation coefficient heat map, see Figure 9 .

[0111] Figure 9 ...

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Abstract

The invention discloses a method for determining dose-effect of a traditional Chinese medicine compound on the basis of variable importance in projection. Compared with the prior art, the research method for determining the dose-effect relationship of a traditional Chinese medicine compound on the basis of variable importance in projection has the advantages as follows: 1, the most important in-blood ingredient variable is acquired through analysis of in-blood ingredients with the method based on variable importance in projection, analysis of the in-blood ingredients is superior to that of ingredients of the compound, and a scheme calculated with the method is accurate and reliable; 2, according to the method, a threshold of a clinically recommended medicine is given on the basis that the dose-effect relationship is determined, valuable reference advice can be proposed for the clinic medicine, and direct cognition is provided for prediction of the clinic medicine through a dose-effect curve fitting equation; 3, according to the method, the in-blood ingredients of the traditional Chinese medicine compound are adopted for dose-effect analysis, so that the analysis result is more reasonable and accurate; 4, a result of the method is displayed through patterns, and accordingly, people can better understand the analysis result.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compound prescriptions, and in particular relates to a method for determining the dose-effect of traditional Chinese medicine compound prescriptions based on variable importance projection analysis and giving a clinically recommended dosage threshold. Background technique [0002] Traditional Chinese medicine is a treasure that the Chinese nation has used for thousands of years to treat diseases and keep fit. The relationship between dosage and effect of Chinese herbal compound is a reference to guide clinical medication, and it is also a guarantee of whether the Chinese herbal compound can play a key therapeutic role. How to effectively determine the relationship between the dosage and effect of traditional Chinese medicine compound is an urgent task for clinical medication. Therefore, it has certain practical significance and economic value to find out an efficient, accurat...

Claims

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Application Information

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IPC IPC(8): G01N33/15G06F17/11
Inventor 杜建强王跃生饶毅聂斌郝竹林朱志鹏
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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