Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of miRNA molecules in diagnosis and prognosis of schizophrenia

A technology for schizophrenia and purpose, applied in the field of diagnosis and prognosis of schizophrenia, which can solve problems such as falling back and rising

Active Publication Date: 2015-12-09
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
View PDF5 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0026] The present inventors found that miR-130b and miR-193a-3p significantly increased in schizophrenia plasma, and confirmed that the expression of miR-130b and miR-193a-3p has the specificity of schizophrenia disease state, and, in the treatment The expression of miR-130b and miR-193a-3p decreased significantly in the plasma of patients who achieved remission, but did not change significantly in the plasma of patients who did not achieve remission

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of miRNA molecules in diagnosis and prognosis of schizophrenia
  • Use of miRNA molecules in diagnosis and prognosis of schizophrenia
  • Use of miRNA molecules in diagnosis and prognosis of schizophrenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0038] 1. Clinical data collection and evaluation

[0039] The research objects included in this study are divided into two parts: the inpatients from the Department of Mental Health of the First Hospital of Shanxi Medical University from March 2000 to August 2008; (ClinicalTrials.govIdentifier: NCT01057849), collected from March 2006 to December 2009, from five mental health centers in China, namely the Sixth Hospital of Peking University, Beijing Huilongguan Hospital, Shanghai Mental Health Center, Huaxi affiliated to Sichuan University The Mental Health Center of the Hospital, and the Mental Health Research Institute of the Second Xiangya Hospital of Central South University.

[0040] Inclusion criteria for patients with paranoid schizophrenia:

[0041] (1) Sign the informed consent form by yourself or your guardian;

[0042] (2) Han nationality;

[0043] (3) Evaluated by the diagnostic tool DSM-Ⅳ-TR axis I disorder clinical stereotype examination (patient version) (Stru...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Sensitivityaaaaaaaaaa
Sensitivityaaaaaaaaaa
Sensitivityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a use of miRNA molecules in diagnosis and prognosis of schizophrenia, especially relates to a use of miR-130b and miR-193a-3p in diagnosis and prognosis of schizophrenia, and also relates to a use of one or more primers and / or probes for specifically detecting the content of the miR-130b or the miR-193a-3p in blood plasma in preparation of reagents for diagnosis or prognosis of schizophrenia patients.

Description

technical field [0001] The present invention relates to the use of miRNA molecules in the diagnosis and prognosis of schizophrenia. In particular, the present invention relates to the use of miR-130b and miR-193a-3p in the diagnosis and prognosis of schizophrenia. Background technique [0002] Schizophrenia (MIM181500) is one of the most common clinical severe mental disorders. It is a syndrome that has a severe impact on the inner and outer sense of reality, mainly manifested as disturbances in perception, thinking, emotion, speech and activities and incoordination of mental activities and the environment. Generally, there is no intellectual disability, and some patients may experience cognitive impairment during the course of the disease. The lifetime prevalence of this patient population is about 1%. The onset is mostly in late adolescence and early adulthood, and the incidence rate of men and women is equal, and the average age of onset in men is earlier than that in ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 许琪于欣韦晖原岩波
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com