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Use of miRNA molecules in the diagnosis and prognosis of schizophrenia

A technology of schizophrenia and purpose, applied in the direction of biochemical equipment and methods, microbial determination/inspection, etc., can solve problems such as rise and fall

Active Publication Date: 2018-11-09
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0026] The present inventors found that miR-130b and miR-193a-3p significantly increased in schizophrenia plasma, and confirmed that the expression of miR-130b and miR-193a-3p has the specificity of schizophrenia disease state, and, in the treatment The expression of miR-130b and miR-193a-3p decreased significantly in the plasma of patients who achieved remission, but did not change significantly in the plasma of patients who did not achieve remission

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  • Use of miRNA molecules in the diagnosis and prognosis of schizophrenia

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Embodiment Construction

[0038] 1. Clinical data collection and evaluation

[0039] The research objects included in this study are divided into two parts: the inpatients from the Department of Mental Health of the First Hospital of Shanxi Medical University from March 2000 to August 2008; (ClinicalTrials.gov Identifier: NCT01057849), collected from March 2006 to December 2009, from five mental health centers in China, namely the Sixth Hospital of Peking University, Beijing Huilongguan Hospital, Shanghai Mental Health Center, Sichuan University Affiliated Mental Health Center of West China Hospital, Mental Health Research Institute of the Second Xiangya Hospital of Central South University.

[0040] Inclusion criteria for patients with paranoid schizophrenia:

[0041] (1) Sign the informed consent form by yourself or your guardian;

[0042] (2) Han nationality;

[0043] (3) Evaluated by the diagnostic tool DSM-Ⅳ-TR Axis I disorders (patients edition) (Structured clinical interview for DSM-Ⅳ-TR Axis...

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Abstract

The invention relates to a use of miRNA molecules in diagnosis and prognosis of schizophrenia, especially relates to a use of miR-130b and miR-193a-3p in diagnosis and prognosis of schizophrenia, and also relates to a use of one or more primers and / or probes for specifically detecting the content of the miR-130b or the miR-193a-3p in blood plasma in preparation of reagents for diagnosis or prognosis of schizophrenia patients.

Description

technical field [0001] The present invention relates to the use of miRNA molecules in the diagnosis and prognosis of schizophrenia. In particular, the present invention relates to the use of miR-130b and miR-193a-3p in the diagnosis and prognosis of schizophrenia. Background technique [0002] Schizophrenia (MIM181500) is one of the most common clinical severe mental disorders. It is a syndrome that has a severe impact on the inner and outer sense of reality, mainly manifested as disturbances in perception, thinking, emotion, speech and activities and incoordination of mental activities and the environment. Generally, there is no intellectual disability, and some patients may experience cognitive impairment during the course of the disease. The lifetime prevalence of this patient population is approximately 1%. The onset is mostly in late adolescence and early adulthood, and the incidence rate of men and women is equal, and the average age of onset in men is earlier than ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
Inventor 许琪于欣韦晖原岩波
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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