Application of a traditional Chinese medicine composition for nourishing the kidney and strengthening bones in the preparation of medicines for treating osteoporosis caused by aromatase inhibitors

A technology of aromatase and osteoporosis, which is applied in the direction of drug combination, medical preparations containing active ingredients, medical formulas, etc., can solve the problems of Western medicine without drug treatment, etc.

Inactive Publication Date: 2018-12-14
BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the pathogenesis and treatment of AIMSS are still in the stage of research and exploration. Due to the lack of effective intervention measures, AIMSS will be a major hidden danger for the termination of endocrine therapy and tumor recurrence.
[0003] Long-term use of AIs leads to osteoporosis in patients, and there is no specific drug for treatment in modern Western medicine

Method used

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  • Application of a traditional Chinese medicine composition for nourishing the kidney and strengthening bones in the preparation of medicines for treating osteoporosis caused by aromatase inhibitors

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0020] Experimental Example 1: The effect of Yishen Jiangu Granules on bone mineral density reduction and osteoporosis caused by aromatase inhibitors in breast cancer

[0021] 1. Research methods

[0022] 1.1 Research design: multi-center, randomized, double-blind, placebo-controlled clinical research.

[0023] 1.1.1 Research Center

[0024] All the cases were completed in the Oncology Department of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, the Department of Integrated Traditional Chinese and Western Medicine of Beijing Cancer Hospital, and the outpatient and ward of Guang'anmen Hospital of China Academy of Chinese Medical Sciences.

[0025] 1.1.2 Stochastic method

[0026] In this study, block random method was used.

[0027] 1.1.3 Blind design

[0028] This study adopted a double-blind design.

[0029] 1.1.4 Control settings

[0030] Inter-group comparison between the traditional Chinese medicine group and the control gr...

Embodiment 1

[0074] 1. Prescription:

[0075] Rehmannia glutinosa 200g, Cornus 150g, Dodder 100g, Achyranthes sichuanensis 150 parts, Cyperus cyperi 100g, Angelica 100g, Poria cocos 150g, Paeoniae Alba 150g, Rhizoma chuanxiong 100g, Corydalis 150g, Speranthema 150g, and 200g Tachibana chinensis.

[0076] 2. Preparation method:

[0077] Decoct the medicinal flavor with water for 2 times, the first time for 60 minutes, the second time for 30 minutes, filter, concentrate, add appropriate amount of auxiliary materials, mix well, dry, and granulate to obtain.

Embodiment 2

[0079] 1. Prescription:

[0080] Rehmannia glutinosa 190g, Cornus 170g, Dodder 110g, Achyranthes sichuanensis 120g, Cyperus cyperi 120g, Angelica 170g, Poria cocos 170g, Paeoniae Alba 130g, Rhizoma chuanxiong 120g, Corydalis 130g, Speranthema 160g, and 190g terrazzo.

[0081] 2. Preparation method:

[0082] Decoct the medicinal flavor with water for 2 times, the first time for 60 minutes, the second time for 30 minutes, filter, concentrate, add appropriate amount of auxiliary materials, mix well, dry, and granulate to obtain.

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Abstract

The invention discloses application of a Yishen Jiangu traditional Chinese medicine composition in the preparation of pharmaceuticals used for treating osteoporosis caused by aromatase inhibitors. The traditional Chinese medicine composition comprises 150 to 250 parts of prepared rehmannia root, 100 to 200 parts of dogwood fruit, 60 to 150 g of Chinese dodder seed, 100 to 200 parts of medicinal Cyathula root, 70 to 160 parts of nutgrass galingale rhizome, 70 to 150 parts of Chinese angelica root, 100 to 200 parts of Indian bread, 100 to 200 parts of white peony root, 60 to 150 parts of Szechuan lovage rhizome, 100 to 200 parts of corydalis tuber, 100 to 200 parts of garden balsam stem, and 150 to 250 parts of Chinese starjasmine stem. Clinical experimental studies show that the traditional Chinese medicine composition is applicable to treating bone density reduction and osteoporosis caused by the aromatase inhibitors and has significant effect.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition for nourishing the kidney and strengthening bones, in particular to an application of the traditional Chinese medicine composition for nourishing the kidney and strengthening bones in preparing medicine for treating osteoporosis caused by aromatase inhibitors. Background technique [0002] Third-generation aromatase inhibitors are the standard of care for endocrine therapy in postmenopausal breast cancer patients. The results of multiple international large-scale clinical trials have confirmed that aromatase inhibitors have more definite curative effect and better tolerance than tamoxifen, prolong the recurrence-free survival time, reduce the risk of recurrence, and reduce the incidence of contralateral breast cancer. decline. The incidence of bone and joint symptoms (aromatase inhibitor-associated musculoskeletal symptoms, AIMSS) caused by long-term use of AIs is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61P19/10
Inventor 王笑民杨国旺郁仁存于明薇彭楠
Owner BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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