Application of artesunate in preparation of medicine for treating idiopathic pulmonary fibrosis

A technology for pulmonary fibrosis and artesunate, applied in the field of biomedicine, can solve the problems of high cost, no public report of artesunate idiopathic pulmonary fibrosis drug, lack of donors, etc. Medicinal prospects, efficacy in inhibiting disease progression

Inactive Publication Date: 2015-11-25
AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lung transplantation is currently the most effective treatment for pulmonary fibrosis, but the lack of donors, immune rejection, and high costs limit i

Method used

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  • Application of artesunate in preparation of medicine for treating idiopathic pulmonary fibrosis
  • Application of artesunate in preparation of medicine for treating idiopathic pulmonary fibrosis
  • Application of artesunate in preparation of medicine for treating idiopathic pulmonary fibrosis

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Embodiment Construction

[0028] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

[0029] (1) Establishment of animal model of pulmonary fibrosis

[0030] Eighty male SD rats weighing 180-250 g were purchased from the SPF Animal Experiment Center of Guilin Medical College. They were randomly divided into normal saline control group (abbreviated as NS group), normal saline + bleomycin control group (abbreviated as BLM group), bleomycin + artesunate treatment group (abbreviated as AT group) and normal saline + Artemisia annua group. In the succinate control group (abbreviated as AC group), the rats in each group were randomly divided into 20 rats / group.

[0031] Normal saline control group (NS group): 0.3-0.4 mL of normal saline was injected into the trachea once, and 1 mL of normal saline was inje...

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Abstract

The invention discloses an application of artesunate in preparation of a medicine for treating idiopathic pulmonary fibrosis, and belongs to the field of biological medicines. Through lowering expression of lung tissues and primary cells TIMP-1 and TIMP-2 and increasing expression of MMP-2 and MMP-9, the artesunate is conducive to degradation of IV-type collagen and ECM, so that the target of treating idiopathic pulmonary fibrosis is reached. The known artesunate is used for preparing the medicine for treating malaria; the new application field is opened up; the problems that the existing medicine for treating idiopathic pulmonary fibrosis is large in side effect and non-ideal in effect are solved; the artesunate has important significance on improvement of the remedy rate of the idiopathic pulmonary fibrosis; the idiopathic pulmonary fibrosis can be effectively prevented and treated; and significant economic benefits and social benefits are brought.

Description

technical field [0001] The invention relates to the application of artesunate, in particular to the application of artesunate in the preparation of medicines for treating idiopathic pulmonary fibrosis, and belongs to the field of biomedicine. Background technique [0002] Idiopathic pulmonary fibrosis (IPF) is the most refractory chronic fibrotic lung disease, its condition is irreversible, and its mortality rate even exceeds that of many cancers. Its pathological mechanism is complex, and its etiology has not been fully elucidated. The main pathological features are diffuse alveolitis, inflammation of the lung parenchyma, and homogeneous fibrosis. Studies have shown that massive deposition of extracellular matrix, leading to the appearance of fibroblast foci, may play a key role in pulmonary fibrosis. Although the clinical treatment of IPF has made great progress in the past decade, the Evidence-Based Guidelines for the Diagnosis and Treatment of Idiopathic Pulmonary Fibr...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61P11/00
CPCY02A50/30
Inventor 王昌明王妍妮莫碧文
Owner AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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