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Method for constructing segmental personalized human urethral three-dimensional stent material

A three-dimensional stent and segmental technology, applied in the medical field, can solve the problem of difficult to achieve precise control of micro-scale structure regulation

Active Publication Date: 2015-11-11
SHANGHAI SIXTH PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the former cannot really achieve the so-called individualized urethra standard on the macro scale, while the latter can achieve individualized simulation on the macro scale, but it is difficult to achieve the goal of precise control on the micro scale structural regulation

Method used

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  • Method for constructing segmental personalized human urethral three-dimensional stent material
  • Method for constructing segmental personalized human urethral three-dimensional stent material
  • Method for constructing segmental personalized human urethral three-dimensional stent material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] In step 1.1, the patient to be tested is placed in a supine position, and the penis and scrotum area and the area of ​​the outer urethra are disinfected.

[0052] Stretch the penis in a weak state, and inject 10ml of tetracaine glue from the outer urethra to seal the outer urethra to prevent the glue from leaking.

[0053] Step 1.2, using Toshiba Aplio500 ultrasonic diagnostic apparatus, probe model PLT-1204MV (center frequency 14MHz). Place the ultrasound probe at the junction of the penis and scrotum to observe the urethral lumen.

[0054] If the ultrasound finds that the urethral lumen is not fully opened, or the opening is not satisfactory. You can continue to inject tetracaine glue until the inner diameter of the urethra opens more than 8mm. If repeating the operation twice fails to open the urethral cavity further, it is deemed that the urethra has stricture.

[0055] The dynamic scanning mode is adopted to scan the urethra and surrounding tissues to obtain coronal imag...

Embodiment 2

[0066] Step 1.1, take the patient to be tested in a supine position, and disinfect the perineum area and the area of ​​the outer urethra.

[0067] Stretch the penis in a weak state, and inject 10ml of tetracaine glue from the outer urethra to seal the outer urethra to prevent the glue from leaking.

[0068] Step 1.2, using Toshiba Aplio500 ultrasonic diagnostic apparatus, probe model PLT-1204MV (center frequency 14MHz). Place the ultrasound probe in the perineum and observe the urethral lumen.

[0069] If the ultrasound finds that the urethral lumen is not fully opened, or the opening is not satisfactory. You can continue to inject physiological saline until the inner diameter of the urethra opens more than 8mm. If repeating the operation twice fails to open the urethral cavity further, it is deemed that the urethra has stricture.

[0070] The dynamic scanning mode is adopted to scan the urethra and surrounding tissues to obtain coronal image information of the urethra. The data is...

Embodiment 3

[0083] Step 1.1, take the patient to be tested in a supine position, and disinfect the penis and scrotum area and the area of ​​the outer urethra.

[0084] Stretch the penis in a weak state, and inject 10ml of tetracaine glue from the outer urethra to seal the outer urethra to prevent the glue from leaking.

[0085] Step 1.2, using Toshiba Aplio500 ultrasonic diagnostic apparatus, probe model PLT-1204MV (center frequency 14MHz). Place the ultrasound probe at the junction of the penis and scrotum. Observe the lumen of the urethra.

[0086] If the ultrasound finds that the urethral lumen is not fully opened, or the opening is not satisfactory. You can continue to inject tetracaine glue until the inner diameter of the urethra opens more than 8mm. If repeating the operation twice fails to open the urethral cavity further, it is deemed that the urethra has stricture.

[0087] The dynamic scanning mode is adopted to scan the urethra and surrounding tissues to obtain coronal image informa...

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Abstract

The invention discloses a method for constructing a segmental personalized human urethral three-dimensional stent material. The method includes: utilizing a three-dimensional ultrasonic technology to acquire integral imaging information of a thin-layer penis of a patient; utilizing a manual sketching method to screen a to-be-constructed image area in the integral imaging information; utilizing the three-dimensional technology to perform three-dimensional reconstruction and processing on the to-be-constructed image area, guiding the to-be-constructed image area into a three-dimensional printer for printing, preparing a urethral model, and constructing a silica gel model supportive of material filling after subjecting the urethral model to membrane reversing through a silica gel membrane reversing process; disposing a filling material into the silica gel model for reorganization to construct the human urethral three-dimensional stent material with personalized features. A solid model constructed by the method is fitted with physiological dissection position structure of a normal human urinary tract and meets personalized features of the patient, and the constructed material has the advantage of being multiscale controllable at both macro and micro levels.

Description

Technical field [0001] The invention belongs to the field of medical technology, and relates to a method for constructing a medical human tissue scaffold material, in particular to a method for constructing segmental individualization using three-dimensional ultrasound imaging tools, three-dimensional printing technology, combined with inverted membrane technology and biomaterial preparation technology The method of three-dimensional stent material for human urethra. Background technique [0002] In the past ten years, the attention paid to the treatment of urethral strictures under complex conditions has been showing a trend of increasing. Although the current clinical gold standard for urethral repair and replacement surgery is still to use a variety of autologous tissues such as penile flaps, buccal mucosa, tongue mucosa and even colon mucosa for reconstruction. However, the introduction of the concept of tissue engineering in this field has made the status of this gold stand...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/22A61L27/20A61L27/18A61L27/56B33Y10/00
Inventor 冯超李喆吕向国陈磊胡兵陈仕艳徐月敏王华平
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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