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Pain easing medicinal composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of poor efficacy of analgesics, large adverse reactions and the like

Inactive Publication Date: 2015-11-11
沈阳华泰药物研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a safer and more effective analgesic pharmaceutical composition and its application, solve the problem of poor curative effect or relatively large adverse reactions of analgesics in current clinical application, and improve the quality of life of pain patients

Method used

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  • Pain easing medicinal composition and application thereof
  • Pain easing medicinal composition and application thereof
  • Pain easing medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Mouse acetic acid writhing method to investigate the analgesic effect of the composition

[0028] Dozens of mice, half male and half male, were randomly divided into groups of 8 mice, and given intravenous injection of normal saline, Nefopam prepared with normal saline, acetaminophen and composition solutions of different proportions. After 30 minutes, 0.1ml / 10g body weight of 0.8% glacial acetic acid aqueous solution (freshly prepared) was injected intraperitoneally, timed immediately, and the number of writhing times of mice within 20 minutes was observed. The experimental results are shown in Table 2.

[0029] Table 2 Inhibition of acetic acid writhing reaction

[0030]

[0031] The above results show that Nefopam 4mg / kg and different proportioning Nefopam+paracetamol compositions have obvious inhibitory effect on the acetic acid writhing reaction, and the analgesic effects are equivalent, while the compositions of each proportioning The dosage of Nefo...

Embodiment 2

[0040] Embodiment 2 repeats the orthogonal experiment

[0041] The number of animals, grouping, administration, and experimental methods are all the same as "1". See Table 4 for the experimental results, and Table 5 for the results of the orthogonal design analysis. Result analysis and explanation:

[0042] 1) M1, M2, and M3 are the sum of the number of writhing times at levels 1, 2, and 3 of the column respectively

[0043] 2) Paracetamol column M1=23.0, M2=26.9, M3=22.5

[0044] 3) Nefopam M1=35.8, M2=25.6, M3=11.0

[0045] 4) the above numerical value is small, and it can be seen that Nefopam is the main factor affecting drug efficacy, consistent with the above-mentioned experimental results (Table 2 and Table 3), the optimal level of Nefopam is M3 i.e. 3.5mg / kg, The optimal level of acetaminophen is M3, which is 130mg / kg, but the first level of acetaminophen, namely 60mg / kg, is close to the third level of 130mg / kg. This result is basically consistent with the result of...

Embodiment 3

[0053] The analgesic effect of embodiment 3 optimal proportion composition (mouse acetic acid writhing method)

[0054] Dozens of mice, half male and half female, were randomly divided into groups, 10 mice per group, and given intravenous injection of normal saline, Nefopam prepared with normal saline and composition solutions with different ratios. After 30 minutes, 0.1ml / 10g body weight of 0.8% glacial acetic acid aqueous solution (freshly prepared) was injected intraperitoneally, timed immediately, and the number of writhing times of mice within 20 minutes was observed. The results are shown in Table 6.

[0055] The analgesic effect of table 6 optimal compound (mouse acetic acid writhing method)

[0056]

[0057] From Table 6 and Figure 4It can be seen that the optimal compound (3.5mg / kg Nefopam + 60mg / kg acetaminophen) has a significant analgesic effect, and the average number of writhing times is 6.0±1.0 (compared with normal saline, **P Figure 5 ). Nefopam single ...

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Abstract

The invention provides a pain easing medicinal composition and an application thereof to solve the problem of poor curative effects or large untoward effects of pain easing medicines clinically applied at present and improve the living quality of patients with pains. The composition contains nefopam and paracetamol. The composition makes nefopam have an obvious pain easing effect under a small dosage, prolongs the pain easing action time, and has slightly better long-term administration tolerance than single nefopam.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an analgesic pharmaceutical composition and application thereof. Background technique [0002] Pain is a protective mechanism of the body itself, which not only enables the body to avoid some dangerous stimuli that may damage the body, but also serves as an alarm for the abnormal state of the body. But at the same time, pain may also cause harm to the body. Its existence will cause changes in psychological and emotional behaviors, become a malignant stimulus, and cause changes in the functions of the autonomic nervous system and endocrine system, resulting in increased heart rate, increased blood pressure, Sweating, increased muscle tension, changes in the blood system, endocrine and immune system disorders and other phenomena have seriously affected people's lives. At present, the commonly used clinical analgesics are mainly divided into three categories: non-stero...

Claims

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Application Information

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IPC IPC(8): A61K31/395A61P29/00A61K31/167
Inventor 王利杰薛昊王鹏
Owner 沈阳华泰药物研究有限公司
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