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A drug-retaining microneedle matrix and its manufacturing method

A micro-needle and drug technology, applied in the directions of micro-needle, drug devices, needles, etc., can solve the problems of no indication that the drug is peeled off, the quantitative drug delivery effect is not ideal, and it is cumbersome.

Active Publication Date: 2019-02-15
COSMED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods are very cumbersome to implement, and these methods do not suggest the technology to prevent the medicament from being peeled off when the microneedles penetrate the skin, and the quantitative administration effect is not ideal.

Method used

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  • A drug-retaining microneedle matrix and its manufacturing method
  • A drug-retaining microneedle matrix and its manufacturing method
  • A drug-retaining microneedle matrix and its manufacturing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Using nylon 12 as material, the microneedle matrix with microneedles with stepped parts and the microneedle matrix with microneedles without stepped parts were manufactured by injection molding. figure 1 It shows the structure of one microneedle with a stepped part among the plurality of microneedles arranged in the microneedle matrix. In the figure, 1 is a tip portion, 2 is a step portion, 3 is a root portion, and 4 is a base plate. The tip length is 200 μm, the root length is 430 μm, the step edge size is 30 μm, and the needle gap is 400 μm.

[0066] Partially immerse the microneedle tips of two microneedle arrays (diameter 1 cm) from the tip to 100 μm in an aqueous solution of hyaluronic acid (FCH-80LE Kikkoman-Biochemifa Co., Ltd.) and blue pigment (Blue No. 1, NacalaiTesque Co., Ltd.) middle. Blue pigments are used instead of medicines to easily observe the adhesion state of medicines under microscope observation.

[0067] For microneedles with steps, after the ...

Embodiment 2

[0071] Using nylon 12 (L1640Daicel-Degussa Co., Ltd.) as raw material, the microneedle matrix with steps was prepared by injection molding. The dimensions of the microneedles are as follows: tip length 270 μm, tip upper diameter 20 μm, tip lower diameter 60 μm, root length 160 μm, root lower diameter 140 μm, root upper diameter 130 μm, edge size 35 μm, needle gap 400 μm. Among them, the upper part and the lower part are based on the state where the tip part is placed on the top and the root part is placed on the bottom. The diameter of the microneedle matrix is ​​1 cm. image 3 A micrograph showing the formed microneedle. In addition, microneedles with stepped portions were produced with the same tip size and needle gap, and changed the root size so that the edge size was 50 and 100 μm, respectively.

[0072] The effectiveness of the step was evaluated by changing the size of the edge of the step.

[0073] When the size of the edge portion of the step portion is smaller tha...

Embodiment 3

[0079] Polyglycolic acid (Kuredux, Kureha Co., Ltd.) was used as a raw material, and injection molding was performed under the same conditions as in Example 2 except that the injection temperature was 260° C., to obtain a microneedle with a stepped portion with a step edge size of 35 μm. Using this microneedle, a 90 μm tip portion of the microneedle was immersed in an aqueous solution containing 10% of hydroxypropylcellulose (HPC-L, Soda Co., Ltd.) and 0.1% of a red pigment (Red No. 102, Nacalai Tesque Co., Ltd.). After lifting and drying and dipping and drying again, the coating state of the red pigment on the tip of the needle was observed with a solid microscope, and it was found that the red pigment stopped at the step.

[0080] This result shows that the result of Example 2 is not unique to the blue pigment.

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PUM

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Abstract

The present invention provides a drug-retaining microneedle matrix, in which drugs are coated only on the tips of the microneedles, the drugs can be retained quantitatively, and the drugs can be retained in a state that does not peel off when inserted. A microneedle matrix for holding medicines, comprising: a microneedle matrix, and medicines, wherein the microneedle matrix has: a microneedle substrate (4), and microneedles, and the microneedles are placed on the microneedle substrate (4) A plurality of tip parts (1) protrude through the step part (2), and the drug is held on the tip part (1) and the step part (2) of the above-mentioned microneedle.

Description

technical field [0001] The present invention is related to the quantitative drug delivery technology, which is realized by providing a stepped portion on the microneedle for holding the drug. Background technique [0002] The usual methods of administration to the human body include oral administration and transdermal administration. Injection is typically a transdermal method of administration. However, injection needs to be done by professionals such as doctors and nurses and is accompanied by pain, and it is more likely to be infected with AIDS and hepatitis B. It is not an ideal method for most people. In view of this reality, painless transdermal drug delivery using a microneedle matrix has recently attracted attention (Non-Patent Document 1). [0003] When transdermal administration is carried out, the stratum corneum of the skin hinders the penetration of the drug, so simply applying the drug to the surface of the skin results in poor drug penetration. The method o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61L31/00
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 权英淑神山文男山田智也
Owner COSMED PHARMA
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