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pig Lgr5 gene and applications thereof

A gene and gene sequence technology, applied in the field of livestock molecular biology, can solve problems such as few studies, and achieve the effect of promoting cell proliferation and accelerating cell repair.

Active Publication Date: 2015-08-05
SOUTH CHINA AGRI UNIV
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  • Claims
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Problems solved by technology

[0003]The Lgr5 gene is located on human chromosome 12 12q22-q23, mouse chromosome 10 D2|10, rat (Rattus norvegicus) chromosome 7 7q22, rhesus macaque ( Macaca mulatta) on chromosome 11,

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  • pig Lgr5 gene and applications thereof
  • pig Lgr5 gene and applications thereof
  • pig Lgr5 gene and applications thereof

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Abstract

The present invention belongs to the technical field of livestock molecular biology, and particularly discloses a pig Lgr5 gene and applications thereof, wherein the gene sequence is represented by SEQ ID NO:1. According to the present invention, the human Lgr5 gene and the mouse Lgr5 gene are adopted as the reference sequence, the specific primers are designed, and the RACE, the ordinary PCR, and the overlap PCR are used to firstly clone the pig Lgr5 cDNA; the subsequent study results show that the cell proliferation can be promoted and the cell damage repair can be accelerated with the over-expression of the Lgr5 gene; and the Lgr5 provides the important foundation for the subsequent pig Lgr5 function research and the intestinal stem cell research.

Description

technical field [0001] The invention relates to the technical field of livestock molecular biology, in particular to a porcine Lgr5 gene and its application. Background technique [0002] Lgr5, also known as GPR49, HG38, FEX, is a member of the G-protein coupled receptor superfamily and is a macromolecular protein composed of 18 leucine-rich repeat units and 7 transmembrane regions; the latest research proves that , Lgr5 is a target gene downstream of the Wnt signaling pathway, and can be used as a stem cell marker in intestines and other parts. The products expressed by Lgr5 play an important role in the development of embryos and organs, as well as the occurrence and development of various tumors. [0003] The Lgr5 gene is located on human chromosome 12 12q22-q23, mouse chromosome 10 D2|10, rat (Rattus norvegicus) chromosome 7 7q22, rhesus macaque (Macaca mulatta) chromosome 11, and bovine (Bos taurus) chromosome 5 , on chromosome 1 of domestic chicken (Gallus gallus), a...

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Application Information

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IPC IPC(8): C12N15/12C07K14/72C12N15/11C12Q1/68
Inventor 王修启严会超高春起陈荣强李长茂
Owner SOUTH CHINA AGRI UNIV
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