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Method of exciting ions in linear ion well

A technology of linear ion trap and excited ions, which is applied in the direction of ion source/gun, parts of particle separator tube, particle separation tube, etc. It can solve the problem that ions cannot get kinetic energy, fragment ions cannot be detected, and dissociation cannot be realized To achieve the effect of shortening the dissociation time, improving the low quality cut-off problem, improving the fragmentation efficiency and

Inactive Publication Date: 2015-07-29
FUDAN UNIV
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Problems solved by technology

[0010] To achieve collision-induced dissociation, the value of q must be suitable. If it is too small, the ions will not get enough kinetic energy to achieve dissociation; if it is too large, more fragment ions will not be detected due to the low mass cut-off effect.

Method used

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  • Method of exciting ions in linear ion well
  • Method of exciting ions in linear ion well
  • Method of exciting ions in linear ion well

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specific Embodiment 1

[0051] Specific embodiment 1, the schematic diagram of voltage signal application is as figure 2 . The ion trap of this scheme selects the linear ion trap with triangular electrodes, and applies the same auxiliary sine wave AC signal AC to the two pairs of electrodes of the ion trap in a dipole manner. The auxiliary AC signal AC output by the measurement and control system is first divided into two channels, one is directly coupled with the radio frequency RF signal and applied to a pair of electrodes, and the other is coupled with the radio frequency RF signal and applied to the other pair of electrodes through a controllable signal switch. The signal switch can control the output or non-output of the auxiliary AC signal in different timing stages. In the actual experiment process, tandem mass spectrometry includes three important stages, ion isolation, ion collision-induced dissociation stage, and ion scanning stage. The switch is only turned on during the ion collision-in...

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Abstract

The invention, which belongs to the technical field of quality analysis instruments, particularly relates to a method of exciting ions in a linear ion well. In the linear ion well, in an ion collision induction and dissociation phase, auxiliary exciting signals are applied to a radial X direction and a radial Y direction at the same time, kinetic energy of the ions in the two directions is improved, collision with a central gas is further carried out to make dissociation happen, the kinetic energy is converted into internal energy, and thus tandem mass spectrometry analysis is realized. The method of the invention has the advantages that kinetic energy of the ions in both the X direction and the Y direction can be enhanced; compared with a traditional dissociation method in which ions are mainly excited in one direction, more kinetic energy is converted into internal energy, and thereby improving the dissociation efficiency, narrowing a reaction time, and improving low mass cutoff effects in the ion well.

Description

technical field [0001] The invention belongs to the technical field of mass analysis instruments, and in particular relates to a method for exciting ions in a linear ion trap. Background technique [0002] Mass spectrometers have been widely used in fields such as biology, food safety, pharmaceutical industry, environmental monitoring and homeland security. It has excellent qualitative and quantitative capabilities for chemical substances. Tandem mass spectrometry is the core means to analyze the structure of compounds and determine the types of compounds. In mass spectrometry, there are a series of tandem mass spectrometry methods, such as infrared multiphoton dissociation, electron transfer dissociation, electron capture dissociation, proton transfer dissociation and collision-induced dissociation, etc. Among them, collision-induced dissociation is the most widely used due to its advantages of easy implementation and easy prediction of products. [0003] Linear ion trap...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/10
CPCH01J49/063H01J49/0063H01J49/165H01J49/4225H01J49/423
Inventor 党乾坤谢小东徐福兴陈银娟丁传凡
Owner FUDAN UNIV
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