Application of mussel meat oligosaccharides in the preparation of hypoglycemic drugs and its preparation method

Abstract

The invention relates to the application of mussel meat oligosaccharides in the preparation of blood sugar-lowering and anti-diabetic drugs or health food and its preparation method. The mussel meat oligosaccharide is preferably a mussel meat oligosaccharide compound with a molecular weight ranging from 500-2000, and its total content is higher than 50%. Experiments have proved that: mussel oligosaccharides can significantly inhibit the blood sugar level of alloxan-induced diabetic model mice and improve glucose tolerance; It has a significant hypoglycemic effect, mainly manifested in improving the abnormal glucose tolerance of type Ⅱ diabetic rats, inhibiting the increase of plasma HbA1c, significantly increasing the content of liver glycogen and muscle glycogen, strengthening the utilization of liver sugar and inhibiting the production of glycogen. Inhibit the secretion of glucagon, enhance the storage of glycogen and reduce the neogenesis of sugar; the acute toxicity test shows that mussel oligosaccharides have no toxic side effects and are highly safe.

Description

technical field [0001] The invention relates to a new therapeutic application of mussel meat oligosaccharides and a preparation method thereof. Background technique [0002] With the rapid development of the economy and the acceleration of industrialization, human health is facing an increasing threat from non-communicable diseases, and the prevalence of diabetes and the number of diabetic patients have risen sharply. Diabetes and its complications have brought serious burdens to human health and social development. According to the statistics of the International Diabetes Federation (IDF), there were 151 million diabetic patients in the world in 2000, and the current diabetic patients have reached 285 million. According to the current growth rate, it is estimated that nearly 500 million people worldwide will suffer from diabetes by 2030 . It is worth noting that diabetes is not only a "disease of the rich" in developed countries, but developing countries including China h...

AI Technical Summary

Problems solved by technology

In 2008, the Diabetes Epidemiological Survey organized by the Diabetes Society (CDS) of the Chinese Medical Association showed that among people over 20 years old, the age-standardized prevalence of diabetes was 9.7%, and the proportion of prediabetes was as high as 12.8%. , which is equivalent to 1 out of 4 adults with hyperglycemia. What is more serious is that 60.7% of diabetic patients in my country have not been diagnosed and cannot be effectively treated early

At present, the molecular weight of mussel polysaccharides obtained by common extraction methods is generally relatively large, which is not easy to absorb and has weak biological activity, which limits the application of mussel polysaccharides in clinical medicine.

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